review · Methods in molecular biology · 2008
Angiogenic Signalling Pathways
Cited by 77Abstract and details only
Abstract
Hypoxia is widely recognised as a key driving force for tumor angiogenesis by its induction of vascular endothelial growth factor (VEGF) and other direct-acting angiogenic factors. We describe the effect of hypoxia on gene expression and downstream angiogenic signalling; however, the angiogenic process is complex, and many other signalling pathways beyond VEGF are implicated in the formation of new vessels. These include extra-cellular signalling pathways such as the notch/delta, ephrin/Eph receptor, roundabout/slit, and netrin/UNC (uncoordinated) receptor families as well as intracellular proteins such as hedgehog and sprouty. The remarkable diversity in angiogenic signalling pathways provides many opportunities for therapeutic intervention, and anti-angiogenesis is currently a major area of oncology research.
Cite this paper
Ahmed, Z., & Bicknell, R. (2008). Angiogenic Signalling Pathways. Methods in molecular biology, 467, 3–24. https://doi.org/10.1007/978-1-59745-241-0_1
Ahmed, Zubair, and Roy Bicknell. “Angiogenic Signalling Pathways.” Methods in molecular biology, vol. 467, 2008, pp. 3–24, https://doi.org/10.1007/978-1-59745-241-0_1.
Ahmed, Zubair, and Roy Bicknell. 2008. “Angiogenic Signalling Pathways.” Methods in molecular biology 467: 3–24. https://doi.org/10.1007/978-1-59745-241-0_1.
Ahmed, Z. and Bicknell, R. (2008) ‘Angiogenic Signalling Pathways’, Methods in molecular biology, 467, pp. 3–24. Available at: https://doi.org/10.1007/978-1-59745-241-0_1.
@article{ahmed2008angiogenic,
title = {{Angiogenic Signalling Pathways}},
author = {Ahmed, Zubair and Bicknell, Roy},
journal = {Methods in molecular biology},
volume = {467},
pages = {3--24},
year = {2008},
doi = {10.1007/978-1-59745-241-0_1}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.