article · Proceedings of the Royal Society of London. Series B, Biological sciences · 1953

Fundamental dimensions of polypeptide chains

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Abstract

Abstract The dimensions of the polypeptide chain and of its associated N—H•••O hydrogen bonds can be inferred with confidence. Data from many sources—X-ray diffraction analyses of crystals of organic acids, amides, peptides and related compounds; polarized infra-red studies of crystals—together with fundamental concepts of structural chemistry, now provide a basis for satisfactory knowledge and understanding of the dimensions and configurations of the amide group, C H / C'—N // C C The normal coplanarity of the atoms of this group is the result of resonance which gives rise to partial double-bond character of the N—C′ peptide bond. Rotation about this bond is, in general, severely restricted. The trans configuration of the amide group appears to be preferred. Interatomic distances and bond angles of the amide group which may be derived from the present data are: N—C = 1·47 Å C—N—C′ = 123° N—C′ = 1·32 C—N—H = 114 C′—O = 1·24 H—N—C′= 123 C′—C = 1·53 N—C′—O = 125 N—C′—C = 114 O—C′—C = 121 C′—C—N = 110 The dimensions and directional characteristics of N—H•••O hydrogen bonds have been determined in a great variety of crystals. In these crystals the N•••O distances vary, falling generally within the limits 2·79 ± 0·12 Ä. The H•••O vector rarely makes an angle greater than 20° with the probable direction of the N—H bond.

Cite this paper

APA 7

Corey, R. B., & Pauling, L. (1953). Fundamental dimensions of polypeptide chains. Proceedings of the Royal Society of London. Series B, Biological sciences, 141(902), 10–20. https://doi.org/10.1098/rspb.1953.0011

MLA 9

Corey, Robert B., and Linus Pauling. “Fundamental dimensions of polypeptide chains.” Proceedings of the Royal Society of London. Series B, Biological sciences, vol. 141, no. 902, 1953, pp. 10–20, https://doi.org/10.1098/rspb.1953.0011.

Chicago

Corey, Robert B., and Linus Pauling. 1953. “Fundamental dimensions of polypeptide chains.” Proceedings of the Royal Society of London. Series B, Biological sciences 141 (902): 10–20. https://doi.org/10.1098/rspb.1953.0011.

Harvard

Corey, R.B. and Pauling, L. (1953) ‘Fundamental dimensions of polypeptide chains’, Proceedings of the Royal Society of London. Series B, Biological sciences, 141(902), pp. 10–20. Available at: https://doi.org/10.1098/rspb.1953.0011.

BibTeX

@article{corey1953fundamental,
  title = {{Fundamental dimensions of polypeptide chains}},
  author = {Corey, Robert B. and Pauling, Linus},
  journal = {Proceedings of the Royal Society of London. Series B, Biological sciences},
  volume = {141},
  number = {902},
  pages = {10--20},
  year = {1953},
  doi = {10.1098/rspb.1953.0011}
}

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