article · Acta Oto-Laryngologica · 2004
Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss
Simón I. Angeli, Xue Z. Liu, Denise Yan, Thomas J. Bałkany, Fred Telischi
Cited by 13Abstract and details only
Abstract
Conclusion CoQ10 may be helpful in delaying the progression of hearing loss in patients with the 7445A→G mitochondrial mutation. Objective To assess the effect of an antioxidant drug (Coenzyme Q-10) on the hearing level of patients with the mitochondrial DNA 7445A→G mutation and associated sensorineural hearing loss (SNHL). Material and methods We identified three patients with bilateral non-syndromic SNHL harboring the mitochondrial 7445A→G mutation. Two patients had a family history of hearing loss with a strong matrilineal inheritance. The other patient did not have a family history of hearing loss. Two patients (1 with familial and 1 with sporadic SNHL) received treatment with 75 mg of Coenzyme Q-10 (CoQ10) twice a day for 1 year. The remaining patient with a familial form of hearing loss did not agree to take the treatment. Average bone conduction pure-tone thresholds for 0.5, 1, 2 and 4 kHz were obtained before and after diagnosis of mitochondrial hearing loss, and before and after treatment with CoQ10. Results CoQ10-treated patients did not show any additional deterioration of their SNHL after 12 (familial case) and 13 months (sporadic case). The progression rate of SNHL was 6 dB/year in the 2 years prior to initiation of treatment in the familial case who received CoQ10 treatment. One year after being diagnosed with mitochondrial hearing loss, the patient who refused CoQ10 treatment exhibited an 11-dB deterioration of his hearing thresholds. There were no side-effects related to treatment with CoQ10.
Cite this paper
Angeli, S. I., Liu, X. Z., Yan, D., Bałkany, T. J., & Telischi, F. (2004). Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss. Acta Oto-Laryngologica, 125(5), 510–512. https://doi.org/10.1080/00016480510026232
Angeli, Simón I., et al. “Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss.” Acta Oto-Laryngologica, vol. 125, no. 5, 2004, pp. 510–12, https://doi.org/10.1080/00016480510026232.
Angeli, Simón I., Xue Z. Liu, Denise Yan, Thomas J. Bałkany, and Fred Telischi. 2004. “Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss.” Acta Oto-Laryngologica 125 (5): 510–12. https://doi.org/10.1080/00016480510026232.
Angeli, S.I. et al. (2004) ‘Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss’, Acta Oto-Laryngologica, 125(5), pp. 510–512. Available at: https://doi.org/10.1080/00016480510026232.
@article{angeli2004coenzyme,
title = {{Coenzyme Q-10 treatment of patients with a 7445A→G mitochondrial DNA mutation stops the progression of hearing loss}},
author = {Angeli, Simón I. and Liu, Xue Z. and Yan, Denise and Bałkany, Thomas J. and Telischi, Fred},
journal = {Acta Oto-Laryngologica},
volume = {125},
number = {5},
pages = {510--512},
year = {2004},
doi = {10.1080/00016480510026232}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.