article · International Archives of Allergy and Immunology · 1990

Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting

Erika Jensen‐Jarolim, Finn Matthiesen, Per Stahl Skov, Margarete Tejkl, Ole Oesterballe, Lars K. Poulsen

Cited by 4Abstract and details only

Abstract

Patients allergic to grass pollen were hyposensitized with two major allergenic components or whole extract of timothy grass pollen. Specific IgE, IgG1, and IgG4 formed during immunotherapy were analyzed by immunoblotting. Similar antibody-binding patterns were observed in both patient groups. Inhibition experiments using allergenic components isolated by preparative sodium dodecyl sulphate-polyacrylamide gel electrophoresis indicated that all antigenic components of timothy grass pollen detected in immunoblot dispose of private and cross-reactive determinants for binding of human IgE. The worse clinical outcome of immunotherapy after hyposensitization with two cross-reactive components did, therefore, not correlate with a specific antibody formation pattern.

Cite this paper

APA 7

Jensen‐Jarolim, E., Matthiesen, F., Skov, P. S., Tejkl, M., Oesterballe, O., & Poulsen, L. K. (1990). Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting. International Archives of Allergy and Immunology, 92(3), 254–264. https://doi.org/10.1159/000235186

MLA 9

Jensen‐Jarolim, Erika, et al. “Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting.” International Archives of Allergy and Immunology, vol. 92, no. 3, 1990, pp. 254–64, https://doi.org/10.1159/000235186.

Chicago

Jensen‐Jarolim, Erika, Finn Matthiesen, Per Stahl Skov, Margarete Tejkl, Ole Oesterballe, and Lars K. Poulsen. 1990. “Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting.” International Archives of Allergy and Immunology 92 (3): 254–64. https://doi.org/10.1159/000235186.

Harvard

Jensen‐Jarolim, E. et al. (1990) ‘Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting’, International Archives of Allergy and Immunology, 92(3), pp. 254–264. Available at: https://doi.org/10.1159/000235186.

BibTeX

@article{jensenjarolim1990hyposensitization,
  title = {{Hyposensitization Therapy with Whole Pollen Extract or Purified Allergens Monitored by Immunoblotting}},
  author = {Jensen‐Jarolim, Erika and Matthiesen, Finn and Skov, Per Stahl and Tejkl, Margarete and Oesterballe, Ole and Poulsen, Lars K.},
  journal = {International Archives of Allergy and Immunology},
  volume = {92},
  number = {3},
  pages = {254--264},
  year = {1990},
  doi = {10.1159/000235186}
}

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