review · Environmental Health Perspectives · 1999
Evaluating the effects of endocrine disruptors on endocrine function during development.
Robert M. Bigsby, Robert E. Chapin, G. P. Daston, Brian J. Davis, J. Christopher Gorski, L. Earl Gray, Kembra L. Howdeshell, R. Thomas Zoeller, Frederick S. vom Saal
Cited by 199Open access
Abstract
The major concerns with endocrine disruptors in the environment are based mostly on effects that have been observed on the developing embryo and fetus. The focus of the present manuscript is on disruption of three hormonal systems: estrogens, androgens, and thyroid hormones. These three hormonal systems have been well characterized with regard to their roles in normal development, and their actions during development are known to be perturbed by endocrine-disrupting chemicals. During development, organs are especially sensitive to low concentrations of the sex steroids and thyroid hormones. Changes induced by exposure to these hormones during development are often irreversible, in contrast with the reversible changes induced by transient hormone exposure in the adult. Although it is known that there are differences in embryonic/fetal/neonatal versus adult endocrine responses, minimal experimental information is available to aid in characterizing the risk of endocrine disruptors with regard to a number of issues. Issues discussed here include the hypothesis of greater sensitivity of embryos/fetuses to endocrine disruptors, irreversible consequences of exposure before maturation of homeostatic systems and during periods of genetic imprinting, and quantitative information related to the shape of the dose-response curve for specific developmental phenomena.
Cite this paper
Bigsby, R. M., Chapin, R. E., Daston, G. P., Davis, B. J., Gorski, J. C., Gray, L. E., Howdeshell, K. L., Zoeller, R. T., & Saal, F. S. V. (1999). Evaluating the effects of endocrine disruptors on endocrine function during development. Environmental Health Perspectives, 107(suppl 4), 613–618. https://doi.org/10.1289/ehp.99107s4613
Bigsby, Robert M., et al. “Evaluating the effects of endocrine disruptors on endocrine function during development.” Environmental Health Perspectives, vol. 107, no. suppl 4, 1999, pp. 613–18, https://doi.org/10.1289/ehp.99107s4613.
Bigsby, Robert M., Robert E. Chapin, G. P. Daston, Brian J. Davis, J. Christopher Gorski, L. Earl Gray, Kembra L. Howdeshell, R. Thomas Zoeller, and Frederick S. vom Saal. 1999. “Evaluating the effects of endocrine disruptors on endocrine function during development.” Environmental Health Perspectives 107 (suppl 4): 613–18. https://doi.org/10.1289/ehp.99107s4613.
Bigsby, R.M. et al. (1999) ‘Evaluating the effects of endocrine disruptors on endocrine function during development’, Environmental Health Perspectives, 107(suppl 4), pp. 613–618. Available at: https://doi.org/10.1289/ehp.99107s4613.
@article{bigsby1999evaluating,
title = {{Evaluating the effects of endocrine disruptors on endocrine function during development.}},
author = {Bigsby, Robert M. and Chapin, Robert E. and Daston, G. P. and Davis, Brian J. and Gorski, J. Christopher and Gray, L. Earl and Howdeshell, Kembra L. and Zoeller, R. Thomas and Saal, Frederick S. vom},
journal = {Environmental Health Perspectives},
volume = {107},
number = {suppl 4},
pages = {613--618},
year = {1999},
doi = {10.1289/ehp.99107s4613}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.