article · ACS Nano · 2015

Directed Enzymatic Activation of 1-D DNA Tiles

Sudhanshu Garg, Harish Chandran, Nikhil Gopalkrishnan, Thomas H. LaBean, John H. Reif

Cited by 7Abstract and details only

Abstract

The tile assembly model is a Turing universal model of self-assembly where a set of square shaped tiles with programmable sticky sides undergo coordinated self-assembly to form arbitrary shapes, thereby computing arbitrary functions. Activatable tiles are a theoretical extension to the Tile assembly model that enhances its robustness by protecting the sticky sides of tiles until a tile is partially incorporated into a growing assembly. In this article, we experimentally demonstrate a simplified version of the Activatable tile assembly model. In particular, we demonstrate the simultaneous assembly of protected DNA tiles where a set of inert tiles are activated via a DNA polymerase to undergo linear assembly. We then demonstrate stepwise activated assembly where a set of inert tiles are activated sequentially one after another as a result of attachment to a growing 1-D assembly. We hope that these results will pave the way for more sophisticated demonstrations of activated assemblies.

Cite this paper

APA 7

Garg, S., Chandran, H., Gopalkrishnan, N., LaBean, T. H., & Reif, J. H. (2015). Directed Enzymatic Activation of 1-D DNA Tiles. ACS Nano, 9(2), 1072–1079. https://doi.org/10.1021/nn504556v

MLA 9

Garg, Sudhanshu, et al. “Directed Enzymatic Activation of 1-D DNA Tiles.” ACS Nano, vol. 9, no. 2, 2015, pp. 1072–79, https://doi.org/10.1021/nn504556v.

Chicago

Garg, Sudhanshu, Harish Chandran, Nikhil Gopalkrishnan, Thomas H. LaBean, and John H. Reif. 2015. “Directed Enzymatic Activation of 1-D DNA Tiles.” ACS Nano 9 (2): 1072–79. https://doi.org/10.1021/nn504556v.

Harvard

Garg, S. et al. (2015) ‘Directed Enzymatic Activation of 1-D DNA Tiles’, ACS Nano, 9(2), pp. 1072–1079. Available at: https://doi.org/10.1021/nn504556v.

BibTeX

@article{garg2015directed,
  title = {{Directed Enzymatic Activation of 1-D DNA Tiles}},
  author = {Garg, Sudhanshu and Chandran, Harish and Gopalkrishnan, Nikhil and LaBean, Thomas H. and Reif, John H.},
  journal = {ACS Nano},
  volume = {9},
  number = {2},
  pages = {1072--1079},
  year = {2015},
  doi = {10.1021/nn504556v}
}

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