article · The American Journal of Gastroenterology · 2008
Macroscopic Colitis in Microscopic Colitis
Yan Zhao, Yanling Ma, Pabby Vikas, Loren Laine
Cited by 0Abstract and details only
Abstract
Purpose: Microscopic colitis (MC) is a diagnosis based on specific histologic criteria in patients without gross colonic lesions. However, macroscopic mucosal lesions rarely have been reported with MC. We evaluated the association between endoscopic abnormalities and MC and compared the clinical characteristics and outcomes in MC patients with and without endoscopic ulcers/erosions. Methods: Pathology reports from 6/01–2/05 were searched for the cases of MC. The histologic diagnosis was then re-confirmed by a GI pathologist. Demographic, clinical, and laboratory data were collected. The conventional diagnostic criteria of microscopic colitis were used: >6 lymphocytes/100 epithelial cells; increased number of lymphocytes, plasma cells, eosinophils, and mast cells in the lamina propria; no features of ischemia or idiopathic inflammatory bowel disease. A subepithelial collagen band >10 mm differentiated collagenous colitis from lymphocytic colitis. Results: Sixteen patients with microscopic colitis were identified: ages were 37–87 years and 12 were female. Lymphocytic colitis (LC) was found in 9 patients, collagenous colitis (CC) in 7. Three patients had endoscopic ulcers (N = 2) and/or erosions (N = 1), one with LC, two with CC. Pseudomembranes were observed histologically in two patients with CC. Patients with ulcer/erosions were more likely to have more frequent stools, volume depletion, and weight loss (Table 1). Two of three patients denied history of NSAIDs prior to illness, and none tested positive for C. difficile. All three patients responded to treatment (budesonide or 5-ASA) and remained symptom-free for 14–50 month follow-up. One of the three patients had repeat biopsy 2 months and 1 year after treatment, which showed disappearance of pseudomembrane first followed by disappearance of the features of collangenous colitis.Table 1: Characteristics of Patients with and without ulcers/erosionsConclusion: Macroscopic lesions may co-exist with microscopic colitis—possibly representing a severe form of the disease. Macroscopic lesions do not appear to predict a poor clinical outcome in patients with microscopic colitis.
Cite this paper
Zhao, Y., Ma, Y., Vikas, P., & Laine, L. (2008). Macroscopic Colitis in Microscopic Colitis. The American Journal of Gastroenterology, 103, S183. https://doi.org/10.14309/00000434-200809001-00476
Zhao, Yan, et al. “Macroscopic Colitis in Microscopic Colitis.” The American Journal of Gastroenterology, vol. 103, 2008, p. S183, https://doi.org/10.14309/00000434-200809001-00476.
Zhao, Yan, Yanling Ma, Pabby Vikas, and Loren Laine. 2008. “Macroscopic Colitis in Microscopic Colitis.” The American Journal of Gastroenterology 103: S183. https://doi.org/10.14309/00000434-200809001-00476.
Zhao, Y. et al. (2008) ‘Macroscopic Colitis in Microscopic Colitis’, The American Journal of Gastroenterology, 103, p. S183. Available at: https://doi.org/10.14309/00000434-200809001-00476.
@article{zhao2008macroscopic,
title = {{Macroscopic Colitis in Microscopic Colitis}},
author = {Zhao, Yan and Ma, Yanling and Vikas, Pabby and Laine, Loren},
journal = {The American Journal of Gastroenterology},
volume = {103},
pages = {S183},
year = {2008},
doi = {10.14309/00000434-200809001-00476}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.