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article · ACS Nano · 2021

Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device

Zhiheng Cai, Yingqiang Fu, Zhili Qiu, Ying Wang, Wandong Wang, Wenxiang Gu, Zheng Li, Shengyue Wu, Fenglei Gao

Cited by 59Abstract and details only

Abstract

Accurate diagnosis and precise and effective treatment are currently the two magic weapons for dealing with cancer. However, a single marker is often associated with multiple cellular events, which is not conducive to accurate diagnosis, and overly mild treatment methods often make the treatment effect unsatisfactory. In this paper, we construct a Au/Pd octopus nanoparticle-DNA nanomachine (Au/Pd ONP-DNA nanomachine) as a fully automatic diagnosis and treatment logic system. In this system, multiple DNA components are targeting detection units, Au/Pd ONPs act as carriers, and Au/Pd ONPs with an 808 nm laser is the treatment unit. In order to achieve the purpose of precise treatment, we will detect two secondary markers under the premise of detecting one major tumor marker. When all of the designated targets are detected (the logic system input is (1, 1, 1), and the output is (1, 1)), the 808 nm laser can be programmed to automatically radiate tumors and perform photothermal therapy and photodynamic therapy. <i>In vivo</i> and <i>in vitro</i> experiments show that this logic system not only can accurately identify tumor cells but also has considerable therapeutic effects.

Cite this paper

APA 7

Cai, Z., Fu, Y., Qiu, Z., Wang, Y., Wang, W., Gu, W., Li, Z., Wu, S., & Gao, F. (2021). Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device. ACS Nano, 15(12), 19150–19164. https://doi.org/10.1021/acsnano.1c07307

MLA 9

Cai, Zhiheng, et al. “Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device.” ACS Nano, vol. 15, no. 12, 2021, pp. 19150–64, https://doi.org/10.1021/acsnano.1c07307.

Chicago

Cai, Zhiheng, Yingqiang Fu, Zhili Qiu, Ying Wang, Wandong Wang, Wenxiang Gu, Zheng Li, Shengyue Wu, and Fenglei Gao. 2021. “Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device.” ACS Nano 15 (12): 19150–64. https://doi.org/10.1021/acsnano.1c07307.

Harvard

Cai, Z. et al. (2021) ‘Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device’, ACS Nano, 15(12), pp. 19150–19164. Available at: https://doi.org/10.1021/acsnano.1c07307.

BibTeX
@article{cai2021multitarget,
  title = {{Multitarget Reaction Programmable Automatic Diagnosis and Treatment Logic Device}},
  author = {Cai, Zhiheng and Fu, Yingqiang and Qiu, Zhili and Wang, Ying and Wang, Wandong and Gu, Wenxiang and Li, Zheng and Wu, Shengyue and Gao, Fenglei},
  journal = {ACS Nano},
  volume = {15},
  number = {12},
  pages = {19150--19164},
  year = {2021},
  doi = {10.1021/acsnano.1c07307}
}

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