review · Frontiers in Endocrinology · 2022
Advanced Paternal Age and Future Generations
Cited by 37Open access
Abstract
Paternal age at conception has been increasing. In this review, we first present the results from the major mammalian animal models used to establish that increasing paternal age does affect progeny outcome. These models provide several major advantages including the possibility to assess multi- transgenerational effects of paternal age on progeny in a relatively short time window. We then present the clinical observations relating advanced paternal age to fertility and effects on offspring with respect to perinatal health, cancer risk, genetic diseases, and neurodevelopmental effects. An overview of the potential mechanism operating in altering germ cells in advanced age is presented. This is followed by an analysis of the current state of management of reproductive risks associated with advanced paternal age. The numerous challenges associated with developing effective, practical strategies to mitigate the impact of advanced paternal age are outlined along with an approach on how to move forward with this important clinical quandary.
Cite this paper
Chan, P., & Robaire, B. (2022). Advanced Paternal Age and Future Generations. Frontiers in Endocrinology, 13, 897101. https://doi.org/10.3389/fendo.2022.897101
Chan, Peter, and Bernard Robaire. “Advanced Paternal Age and Future Generations.” Frontiers in Endocrinology, vol. 13, 2022, p. 897101, https://doi.org/10.3389/fendo.2022.897101.
Chan, Peter, and Bernard Robaire. 2022. “Advanced Paternal Age and Future Generations.” Frontiers in Endocrinology 13: 897101. https://doi.org/10.3389/fendo.2022.897101.
Chan, P. and Robaire, B. (2022) ‘Advanced Paternal Age and Future Generations’, Frontiers in Endocrinology, 13, p. 897101. Available at: https://doi.org/10.3389/fendo.2022.897101.
@article{chan2022advanced,
title = {{Advanced Paternal Age and Future Generations}},
author = {Chan, Peter and Robaire, Bernard},
journal = {Frontiers in Endocrinology},
volume = {13},
pages = {897101},
year = {2022},
doi = {10.3389/fendo.2022.897101}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.