book chapter · 1995

Antibody Structure and Function

Stephen Searle, Jan T. Pedersen, Andrew Henry, David M. Webster, Anthony R. Rees

Cited by 7Abstract and details only

Abstract

Abstract The remarkably diverse specificity of antibodies can now be explained both in genetic and structural terms. In the early 1970s Wu and Kabat compared the amino acid sequences of immunoglobulin variable domains and showed that certain segments of sequence were more or less conserved while others exhibited high variability between one sequence and another. They proposed that the highly variable segments, or complementarity determining regions (CDRs), formed a contiguous structural element at one end of the antibody that was responsible for antigen recognition. Ip. 1973, this prediction was confirmed by Poljak and coworkers who reported the first X-ray crystallographic structure of an antibody Fab fragment that contained the antigen binding region.

Cite this paper

APA 7

Searle, S., Pedersen, J. T., Henry, A., Webster, D. M., & Rees, A. R. (1995). Antibody Structure and Function. https://doi.org/10.1093/oso/9780195091502.003.0001

MLA 9

Searle, Stephen, et al. “Antibody Structure and Function.” 1995, pp. 3–51, https://doi.org/10.1093/oso/9780195091502.003.0001.

Chicago

Searle, Stephen, Jan T. Pedersen, Andrew Henry, David M. Webster, and Anthony R. Rees. 1995. “Antibody Structure and Function.” https://doi.org/10.1093/oso/9780195091502.003.0001.

Harvard

Searle, S. et al. (1995) ‘Antibody Structure and Function’. Available at: https://doi.org/10.1093/oso/9780195091502.003.0001.

BibTeX

@incollection{searle1995antibody,
  title = {{Antibody Structure and Function}},
  author = {Searle, Stephen and Pedersen, Jan T. and Henry, Andrew and Webster, David M. and Rees, Anthony R.},
  pages = {3--51},
  year = {1995},
  doi = {10.1093/oso/9780195091502.003.0001}
}

Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.