book chapter · Biomarkers in Neuropsychiatry · 2023

Biomarkers in Obsessive-Compulsive Spectrum Disorders

Juliana Braga de Salles Andrade, Angela Rodrigues Souza e Silva, Leonardo F. Fontenelle

Cited by 0Open access

Abstract

Obsessive-compulsive disorder (OCD) is characterized by recurrent and persistent thoughts, urges, or images that result in anxiety or distress (obsessions) and/or repetitive behaviors or mental acts aimed at decreasing the resulting discomfort or performed according to certain rules (compulsions). Its diagnosis relies mostly on the clinical assessment. The first-line treatments for OCD include cognitive-behavioral therapy (CBT) and/or selective serotonin reuptake inhibitors (SSRIs). However, approximately 30% of patients don’t respond to these treatments, and patients may fail to achieve full remission of the symptoms. At the same time, there is a range of syndromes closely related to OCD whose underlying neurobiology remains relatively unexplored. This chapter focuses on addressing two biomarkers reported in samples with obsessive-compulsive and related disorders (OCRDs), namely, inflammatory parameters and neuroimaging findings. In this context, the identification of biomarkers has become promising to improve the accuracy of the diagnosis and to develop a more personalized treatment. For instance, it could help predicting whether a patient with a given OCRD would respond more favorably to a specific treatment.

Cite this paper

APA 7

Andrade, J. B. D. S., Silva, A. R. S. E., & Fontenelle, L. F. (2023). Biomarkers in Obsessive-Compulsive Spectrum Disorders. Biomarkers in Neuropsychiatry, 267–278. https://doi.org/10.1007/978-3-031-43356-6_16

MLA 9

Andrade, Juliana Braga de Salles, et al. “Biomarkers in Obsessive-Compulsive Spectrum Disorders.” Biomarkers in Neuropsychiatry, 2023, pp. 267–78, https://doi.org/10.1007/978-3-031-43356-6_16.

Chicago

Andrade, Juliana Braga de Salles, Angela Rodrigues Souza e Silva, and Leonardo F. Fontenelle. 2023. “Biomarkers in Obsessive-Compulsive Spectrum Disorders.” Biomarkers in Neuropsychiatry: 267–78. https://doi.org/10.1007/978-3-031-43356-6_16.

Harvard

Andrade, J.B.D.S., Silva, A.R.S.E. and Fontenelle, L.F. (2023) ‘Biomarkers in Obsessive-Compulsive Spectrum Disorders’, Biomarkers in Neuropsychiatry, pp. 267–278. Available at: https://doi.org/10.1007/978-3-031-43356-6_16.

BibTeX

@incollection{andrade2023biomarkers,
  title = {{Biomarkers in Obsessive-Compulsive Spectrum Disorders}},
  author = {Andrade, Juliana Braga de Salles and Silva, Angela Rodrigues Souza e and Fontenelle, Leonardo F.},
  booktitle = {Biomarkers in Neuropsychiatry},
  pages = {267--278},
  year = {2023},
  doi = {10.1007/978-3-031-43356-6_16}
}

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