article · International Journal of Molecular Sciences · 2024
The Ribosome Hypothesis: Decoding Mood Disorder Complexity
Vandana Sharma, Karthik Swaminathan, Rammohan Shukla
Cited by 7Open access
Abstract
Several types of mood disorders lie along a continuum, with nebulous boundaries between them. Understanding the mechanisms that contribute to mood disorder complexity is critical for effective treatment. However, present treatments are largely centered around neurotransmission and receptor-based hypotheses, which, given the high instance of treatment resistance, fail to adequately explain the complexities of mood disorders. In this opinion piece, based on our recent results, we propose a ribosome hypothesis of mood disorders. We suggest that any hypothesis seeking to explain the diverse nature of mood disorders must incorporate infrastructure diversity that results in a wide range of effects. Ribosomes, with their mobility across neurites and complex composition, have the potential to become specialized during stress; thus, ribosome diversity and dysregulation are well suited to explaining mood disorder complexity. Here, we first establish a framework connecting ribosomes to the current state of knowledge associated with mood disorders. Then, we describe the potential mechanisms through which ribosomes could homeostatically regulate systems to manifest diverse mood disorder phenotypes and discuss approaches for substantiating the ribosome hypothesis. Investigating these mechanisms as therapeutic targets holds promise for transdiagnostic avenues targeting mood disorders.
Cite this paper
Sharma, V., Swaminathan, K., & Shukla, R. (2024). The Ribosome Hypothesis: Decoding Mood Disorder Complexity. International Journal of Molecular Sciences, 25(5), 2815. https://doi.org/10.3390/ijms25052815
Sharma, Vandana, et al. “The Ribosome Hypothesis: Decoding Mood Disorder Complexity.” International Journal of Molecular Sciences, vol. 25, no. 5, 2024, p. 2815, https://doi.org/10.3390/ijms25052815.
Sharma, Vandana, Karthik Swaminathan, and Rammohan Shukla. 2024. “The Ribosome Hypothesis: Decoding Mood Disorder Complexity.” International Journal of Molecular Sciences 25 (5): 2815. https://doi.org/10.3390/ijms25052815.
Sharma, V., Swaminathan, K. and Shukla, R. (2024) ‘The Ribosome Hypothesis: Decoding Mood Disorder Complexity’, International Journal of Molecular Sciences, 25(5), p. 2815. Available at: https://doi.org/10.3390/ijms25052815.
@article{sharma2024ribosome,
title = {{The Ribosome Hypothesis: Decoding Mood Disorder Complexity}},
author = {Sharma, Vandana and Swaminathan, Karthik and Shukla, Rammohan},
journal = {International Journal of Molecular Sciences},
volume = {25},
number = {5},
pages = {2815},
year = {2024},
doi = {10.3390/ijms25052815}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.