preprint · bioRxiv (Cold Spring Harbor Laboratory) · 2024

Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology

Konstantin Avchaciov, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, M. Petrascheck, П. О. Федичев

Cited by 1Open access

Abstract

Analysis of lifespan-extending compounds suggested the most effective geroprotectors target multiple biogenic amine receptors. To test this hypothesis, we used graph neural networks to predict such polypharmacological compounds and evaluated them in <i>C. elegans</i>. Over 70% of the selected compounds extended lifespan, with effect sizes in the top 5% compared to the DrugAge database. This reveals that rationally designing polypharmacological compounds enables the design of geroprotectors with exceptional efficacy.

Cite this paper

APA 7

Avchaciov, K., Clay, K. J., Denisov, K. A., Burmistrova, O., Petrascheck, M., Petrascheck, M., & Федичев, П. О. (2024). Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.06.23.600269

MLA 9

Avchaciov, Konstantin, et al. “Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology.” bioRxiv (Cold Spring Harbor Laboratory), 2024, https://doi.org/10.1101/2024.06.23.600269.

Chicago

Avchaciov, Konstantin, Khalyd J. Clay, Kirill A. Denisov, Olga Burmistrova, Michael Petrascheck, M. Petrascheck, and П. О. Федичев. 2024. “Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology.” bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.1101/2024.06.23.600269.

Harvard

Avchaciov, K. et al. (2024) ‘Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology’, bioRxiv (Cold Spring Harbor Laboratory). Available at: https://doi.org/10.1101/2024.06.23.600269.

BibTeX

@misc{avchaciov2024multiple,
  title = {{Multiple Targets, One Goal: Compounding life‐extending effects through Polypharmacology}},
  author = {Avchaciov, Konstantin and Clay, Khalyd J. and Denisov, Kirill A. and Burmistrova, Olga and Petrascheck, Michael and Petrascheck, M. and Федичев, П. О.},
  journal = {bioRxiv (Cold Spring Harbor Laboratory)},
  year = {2024},
  doi = {10.1101/2024.06.23.600269}
}

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