other · Figshare · 2023
Flowchart.
Haojie Yu (2363896), Minying Liu (1435813), Xingyue Zhang (1554280), Tingting Ma (228102), Jingchao Yang (5178683), Yaru Wu (3916628), Jie Wang (16762), Muhan Li (731039), Juan Wang (115708), Min Zeng (247802), Liyong Zhang (4819407), Hailong Jin (627101), Xiaoyuan Liu (4692781), Shu Li (136154), Yuming Peng (4819404)
Cited by 0Open access
Abstract
<div><p>Introduction</p><p>Tranexamic acid (TXA) has been proven to prevent thrombolysis and reduce bleeding and blood transfusion requirements in various surgical settings. However, the optimal dose of TXA that effectively reduce intraoperative bleeding and blood product infusion in patients undergoing neurosurgical resection of meningioma with a diameter ≥ 5 cm remains unclear.</p><p>Methods</p><p>This is a single-center, randomized, double-blinded, paralleled-group controlled trial. Patients scheduled to receive elective tumor resection with meningioma diameter ≥ 5 cm will be randomly assigned the high-dose TXA group, the low-dose group, and the placebo. Patients in the high-dose TXA group will be administered with a loading dose of 20 mg/kg TXA followed by continuous infusion TXA at a rate of 5 mg/kg/h. In the low-dose group, patients will receive the same loading dose of TXA followed by a continuous infusion of normal saline. In the control group, patients will receive an identical volume of normal saline. The primary outcome is the estimated intraoperative blood loss calculated using the following formula: collected blood volume in the suction canister (mL)–the volume of flushing (mL) + the volume from the gauze tampon (mL). Secondary outcomes include calculated intraoperative blood loss, intraoperative coagulation function assessed using thromboelastogram (TEG), intraoperative cell salvage use, blood product infusion, and other safety outcomes.</p><p>Discussion</p><p>Preclinical studies suggest that TXA could reduce intraoperative blood loss, yet the optimal dose was controversial. This study is one of the early studies to evaluate the impact of intraoperative different doses infusion of TXA on reducing blood loss in neurological meningioma patients.</p><p>Trial registration</p><p>ClinicalTrials.gov, <a href="https://clinicaltrials.gov/ct2/show/NCT05230381" target="_blank">NCT05230381</a>. Registered on February 8, 2022.</p></div>
Cite this paper
(2363896), H. Y., (1435813), M. L., (1554280), X. Z., (228102), T. M., (5178683), J. Y., (3916628), Y. W., (16762), J. W., (731039), M. L., (115708), J. W., (247802), M. Z., (4819407), L. Z., (627101), H. J., (4692781), X. L., (136154), S. L., & (4819404), Y. P. (2023). Flowchart. Figshare. https://doi.org/10.1371/journal.pone.0290725.g001
(2363896), Haojie Yu, et al. “Flowchart.” Figshare, 2023, https://doi.org/10.1371/journal.pone.0290725.g001.
(2363896), Haojie Yu, Minying Liu (1435813), Xingyue Zhang (1554280), Tingting Ma (228102), Jingchao Yang (5178683), Yaru Wu (3916628), Jie Wang (16762), et al. 2023. “Flowchart.” Figshare. https://doi.org/10.1371/journal.pone.0290725.g001.
(2363896), H.Y. et al. (2023) ‘Flowchart’, Figshare. Available at: https://doi.org/10.1371/journal.pone.0290725.g001.
@misc{23638962023flowchart,
title = {{Flowchart.}},
author = {(2363896), Haojie Yu and (1435813), Minying Liu and (1554280), Xingyue Zhang and (228102), Tingting Ma and (5178683), Jingchao Yang and (3916628), Yaru Wu and (16762), Jie Wang and (731039), Muhan Li and (115708), Juan Wang and (247802), Min Zeng and (4819407), Liyong Zhang and (627101), Hailong Jin and (4692781), Xiaoyuan Liu and (136154), Shu Li and (4819404), Yuming Peng},
journal = {Figshare},
year = {2023},
doi = {10.1371/journal.pone.0290725.g001}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.