other · Figshare · 2024

F test.

Kevin Christian Tjandra (18127527), Robin Novriansyah (18127530), I. Nyoman Sebastian Sudiasa (18127533), Ardiyana Ar (18127536), Nurul Azizah Dian Rahmawati (18127539), Ismail Hadisoebroto Dilogo (9581387)

Cited by 0Open access

Abstract

<div>BackgroundMesenchymal stem cells (MSCs) hold promise for osteoarthritis (OA) treatment, potentially enhanced by combining them with platelet-rich plasma (PRP) and hyaluronic acid (HA). This study aimed to assess the synergy of MSCs, PRP, and varying HA doses, and determine optimal MSC sources to treat early-stage OA in the perspective of Lysholm score, VAS Score, KSS score, and WOMAC score.MethodOriginal articles from 2013 to 2023 were screened from four databases, focusing on clinical trials and randomized controlled trials. The Risk of Bias in Non-randomized Studies—of Interventions (ROB-2) tool evaluated bias, and a PICOS criteria table guided result construction. Revman 5.4 analyzed outcomes such as Lysholm score, VAS score, KSS, WOMAC score, cartilage volume, and defect size using MRI. This systematic review adhered to PRISMA guidelines.ResultNine studies met the final inclusion criteria. Meta-analysis revealed a significant improvement in Lysholm score (MD: 17.89; 95% CI: 16.01, 19.77; I2 = 0%, P = 0.56), a notable reduction in VAS score (MD: -2.62; 95% CI: -2.83, -2.41; I2 = 99%, P < 0.00001), elevated KSS (MD: 29.59; 95% CI: 27.66, 31.52; I2 = 95%, P < 0.0001), and reduced WOMAC score (MD: -12.38; 95% CI: -13.75, -11.01; I2 = 99%, P < 0.0001).ConclusionsArthroscopic guided high-dose subchondral application of primary cultured synovial MSCs in popliteal PRP media with HA effectively regenerates cartilage defects and improves clinical outcomes in early-stage osteoarthritis. Clarification of MSC sources and quantities enhances the understanding of this promising treatment modality.</div>

Cite this paper

APA 7

(18127527), K. C. T., (18127530), R. N., (18127533), I. N. S. S., (18127536), A. A., (18127539), N. A. D. R., & (9581387), I. H. D. (2024). F test. Figshare. https://doi.org/10.1371/journal.pone.0295876.g012

MLA 9

(18127527), Kevin Christian Tjandra, et al. “F test.” Figshare, 2024, https://doi.org/10.1371/journal.pone.0295876.g012.

Chicago

(18127527), Kevin Christian Tjandra, Robin Novriansyah (18127530), I. Nyoman Sebastian Sudiasa (18127533), Ardiyana Ar (18127536), Nurul Azizah Dian Rahmawati (18127539), and Ismail Hadisoebroto Dilogo (9581387). 2024. “F test.” Figshare. https://doi.org/10.1371/journal.pone.0295876.g012.

Harvard

(18127527), K.C.T. et al. (2024) ‘F test’, Figshare. Available at: https://doi.org/10.1371/journal.pone.0295876.g012.

BibTeX

@misc{181275272024test,
  title = {{F test.}},
  author = {(18127527), Kevin Christian Tjandra and (18127530), Robin Novriansyah and (18127533), I. Nyoman Sebastian Sudiasa and (18127536), Ardiyana Ar and (18127539), Nurul Azizah Dian Rahmawati and (9581387), Ismail Hadisoebroto Dilogo},
  journal = {Figshare},
  year = {2024},
  doi = {10.1371/journal.pone.0295876.g012}
}

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