article · ScholarsArchive (Brigham Young University) · 2013

TNF: Structure and Function

Grams, Raymond W., II, McClellan, Dr. David A.

Cited by 0Abstract and details only

Abstract

TNF-á is a cytokine released from activated macrophages and mast cells. It was identified a little over three decades ago as a protein responsible for lysis of certain types of cells, with specificity for tumor cells. Despite hopes as an anti-tumor agent, significant cytotoxic effects have excluded TNF-á from targeted therapies against multiple diseases such as osteoporosis, atherosclerosis, cancer, allograft rejection, and autoimmune disorders. In order to understand the pleiotropic effects expressed by TNF-á, researchers have attempted to map the functional regions of this gene hoping to discover the amino acid residues related to receptor binding and differentiation, and cytotoxicity. Although many residues critical for biological function have been determined, the exact residues responsible for cytotoxicity and receptor binding affinity have not been located.

Cite this paper

APA 7

Grams, R. W. I., & McClellan, D. D. A. (2013). TNF: Structure and Function. ScholarsArchive (Brigham Young University).

MLA 9

Grams, Raymond W., II, and Dr. David A. McClellan. “TNF: Structure and Function.” ScholarsArchive (Brigham Young University), 2013.

Chicago

Grams, Raymond W., II, and Dr. David A. McClellan. 2013. “TNF: Structure and Function.” ScholarsArchive (Brigham Young University).

Harvard

Grams, R.W.I. and McClellan, D.D.A. (2013) ‘TNF: Structure and Function’, ScholarsArchive (Brigham Young University).

BibTeX

@article{grams2013structure,
  title = {{TNF: Structure and Function}},
  author = {Grams, Raymond W., II and McClellan, Dr. David A.},
  journal = {ScholarsArchive  (Brigham Young University)},
  year = {2013}
}

Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.