article · 2014
randomized controlled trial
Intravenous Vitamin C Administration Reduces, Sang-yeon Suh, Woo Kyung Bae, Hong-yup Ahn, Sung-eun Choi, Gyou-chul Jung, Chang Hwan Yeom
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Abstract
Background: Studies of the efficacy of vitamin C treatment for fatigue have yielded inconsistent results. One of the reasons for this inconsistency could be the difference in delivery routes. Therefore, we planned a clinical trial with intravenous vitamin C administration. Methods: We evaluated the effect of intravenous vitamin C on fatigue in office workers. A group of 141 healthy volunteers, aged 20 to 49 years participated in this randomized, double-blind, controlled clinical trial. The trial group received 10 grams of vitamin C with normal saline intravenously, while the placebo group received normal saline only. Since vitamin C is a well-known antioxidant, oxidative stress was measured. Fatigue score, oxidative stress, and plasma vitamin C levels were measured before intervention, and again two hours and one day after intervention. Adverse events were monitored. Results: The fatigue scores measured at two hours after intervention and one day after intervention were significantly different between the two groups (p = 0.004); fatigue scores decreased in the vitamin C group after two hours and remained lower for one day. Trial also led to higher plasma vitamin C levels and lower oxidative stress compared to the placebo group (p < 0.001, p < 0.001, respectively). When data analysis was refined by dividing each group into high-baseline and low-baseline subgroups, it was observed that fatigue was reduced in the lower baseline vitamin C level group after two hours and after one day (p = 0.004). The same did not hold for the higher baseline group (p = 0.206). Conclusion: Thus, intravenous vitamin C reduced fatigue at two hours, and the effect persisted for one day. There were no significant differences in adverse events between two groups. High dose intravenous vitamin C proved to be safe and effective against fatigue in this study. Trial Registration: The clinical trial registration of this trial is
Cite this paper
Reduces, I. V. C. A., Suh, S.-Y., Bae, W. K., Ahn, H.-Y., Choi, S.-E., Jung, G.-C., & Yeom, C. H. (2014). randomized controlled trial.
Reduces, Intravenous Vitamin C Administration, et al. “randomized controlled trial.” 2014.
Reduces, Intravenous Vitamin C Administration, Sang-yeon Suh, Woo Kyung Bae, Hong-yup Ahn, Sung-eun Choi, Gyou-chul Jung, and Chang Hwan Yeom. 2014. “randomized controlled trial.”
Reduces, I.V.C.A. et al. (2014) ‘randomized controlled trial’.
@article{reduces2014randomized,
title = {{randomized controlled trial}},
author = {Reduces, Intravenous Vitamin C Administration and Suh, Sang-yeon and Bae, Woo Kyung and Ahn, Hong-yup and Choi, Sung-eun and Jung, Gyou-chul and Yeom, Chang Hwan},
year = {2014}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.