Samuel D. Stimple, David W. Wood · 2016
This chapter summarizes several advances in the downstream processing of antibodies at industrial scale, with an emphasis on alternatives to conventional protein A affinity batch processing. At the molecular level, these alternatives include the use of newly developed affinity ligands, as well as reemergence of conventional chromatographic processes. The chapter discusses several critical advances in unit operations for the production of monoclonal antibodies (MAbs) reported within the last 20 years, with a focus on novel quasi-continuous downstream purification schemes/platforms being explored in academic and industrial settings. The primary drivers for these advances are based on five central ideals: decreased production costs, equivalent or improved product quality/uniformity, increased flexibility of processing equipment and facilities, elimination of unnecessary process/hold steps, and reduction of plant facilities footprint. There has also been significant effort invested in producing protein A mimetic (PAM) ligands that are less expensive and less prone to degradation under process conditions.
Cited by 0
Koji Koibuchi · Journal of the Japan Society for Precision Engineering · 1995
6 年 9 月 26 日 ** 正 会 員 東京 大学工学部(東 京都文京 区本郷 7-3-1) 1963年 京都 大学大 学 院工学 研 究科 修士 課程 修 了.工 学博士.(株)日 立製 作所機 械研究 所部長, 同 自動車機器事 業部副事業 部長,
Cited by 0Open access
Yuanchang Lin · ScienceDB · 2023
1、Attack_events.xlsx：This document shows all the attacks that occurred on DeFi and divides them into six categories according to the blockchain hardware hierarchy, and shows the distribution of events related to the attacks over the attack categories, as well as the discussion modes of these events.2、Attack_Instances_list.xlsx：This document contains all the attack instances we collected for this project from 2020 to early October 2022, as well as their sources.3、Paper_list.xlsx:This document shows a list of articles discussing attacks that occurred on blockchain, smart contracts, DeFi, and is the primary source for the list of attacks in this paper.4、Project_attack.xlsx:This table shows the overall situation of project-attack related events, which is not overly represented in this paper due to the excessive content and space limitation of the article, and may be used as a direction for future research to explore the association between different types of DeFi projects and events.5、Project_list.xlsx:We have collected some DeFi projects with high TVL from defillama and summarized them in this table. In this paper, we need to use issues and pull requests from github as analysis data, so we must filter out projects with github links and event data, and the filtering results are shown in the table, which is available for review.6、Supplement to Table.xlsx:This document is a supplement to TableVII and VIII in the paper and is attached due to space limitations.The supplement to TableVII shows all the examples of attacks we collected. The supplement to TableVIII shows the average resolution time of the incidents broken down by attack types. In addition to this, there are the results of our statistics on the day of the week on which the attack occurred.7、different_developers_match_results.xlsxThis file is used to record the results of different developers matching attack-related events.8、different_handle_ways.xlsxThis file is used to record the result of the developer matching the way the event was handled.————————1、attack_events.py:This .py file filters out the manually matched event information related to the attack and makes it easier to calculate the average resolution time.2、get_data.py:This .py file is used to crawl all events data of projects.3、raw_data.py:This .py file is used to pre-process the crawled down metadata to retain useful information.4、solved_info.py：This .py file is used to calculate the average resolution time.5、attack_events.zip:Inside this zip is the basic data we have filtered for events related to the attack.6、search_keywords:This folder contains our descriptions of each attack, as well as their literature sources. In addition, it includes the KeyBERT source code we used and the resulting keywords and corresponding scores obtained using KeyBERT.7、calculate_k.pyThis.py file is used to calculate the kappa value and confirm the consistency of manual matching.8、Kruskal-Wallis.pyThe.py file is used to calculate the p value of the Kruskal-Wallis test to confirm the difference.
Cited by 1Open access
SpringerReference · 2011
Cited by 0
Kai Reichel, Nico Hochgeschwender, Holger Voos · 2009
Future applications of unmanned aerial vehicles (UAVs) especially in military missions require the operation of UAVs with a high level of autonomy. Autonomous UAVs could be developed using agent technologies and therefore this paper investigates such an approach from an industrial perspective. Taking into account time, budget and available knowledge on the industrial side and need for UAV operators to understand the behavior of the autonomous system this paper proposes the application of cognitive agents and a design procedure that supports the transition of the pure operational requirements and functional specification into a cognitive agent system, called Operational driven development approach for Cognitive Systems(OpCog).
Cited by 0
Martin H. Weik · 2000
Cited by 0
University of North Dakota. Energy and Environmental Research Center · UND Scholarly Commons (University of North Dakota) · 2019
Fact sheet on the Energy & Environmental Research Center’s chemical process development capabilities, facilities and equipment, and history.
Cited by 0
Alice Theadom (2420), Natalie Hardaker (10098924), Charlotte Bray (10098927) et al. · Figshare · 2021
Cited by 0Open access
Lauren Cadel (6649055), Rasha El-Kotob (4244776), Sander L. Hitzig (6683306) et al. · Figshare · 2025
<div> Adults with spinal cord injury/ dysfunction (SCI/D) commonly take multiple medications for a variety of secondary conditions, and have described challenges with medication self-management. To help support medication self-management, a web-based toolkit, MedManageSCI, was co-designed by our team of researchers and adults with SCI/D, caregivers, and healthcare providers (<a href="https://www.medmanagesci.ca" target="_blank">www.medmanagesci.ca</a>). Together, we co-developed the content areas to include in MedManageSCI, along with the design and brand considerations, to create an initial prototype of the toolkit. To finalize the prototype prior to implementation, the primary objective of this qualitative study was to further refine MedManageSCI by examining the clarity, comprehensiveness, relevance, and delivery of the toolkit modules. Cognitive interviews were conducted virtually between July 2024 and September 2024 with adults with SCI/D (N = 16). A concurrent verbal probing approach using scripted and spontaneous probes was followed. Data were coded using a pre-established coding matrix that aligned with the scripted probes. Participants provided 193 specific modifications to improve the clarity, comprehensiveness, relevance, or delivery of the MedManageSCI toolkit, which were categorized as: Comprehension, Design, and Web-based Delivery. The Comprehension category contained three subcategories: Written Refinements, Ensuring Accessibility, and Revamping Resources. The Design category contained three subcategories: Formatting Content, Streamlining Function, and Enhancing Visuals. Participants perceived the website as an ideal way to deliver the toolkit, noting several benefits of a web-based delivery in comparison to a paper-based toolkit. Overall, participants found the modules to be comprehensive and highly relevant. Further, we discuss the application of cognitive interviews for further refining the MedManageSCI prototype, recommendations to improve the comprehensibility, and the advantages of a web-based toolkit for the SCI/D population. Involving individuals with SCI/D in the development and refinement of self-management materials will help ensure that the content and resources are tailored and appropriate; thereby elevating its likelihood of uptake and dissemination during implementation. </div>
Cited by 0Open access
Fiona M. Dickinson (12245194), Barbara Madaj (3599525), Onesmus M. Muchemi (12245197) et al. · Figshare · 2022
Cited by 0Open access
Anneke van Dijk-de Vries (9510455), Anita Stevens (4024067), Trudy van der Weijden (43498) et al. · Figshare · 2020
Cited by 0Open access
Robin W. M. Vernooij (3628103), Pablo Alonso-Coello (382050), Melissa Brouwers (3451892) et al. · Figshare · 2017
Cited by 0Open access
Gopinath Karmakar, Amol Wakankar, Ashutosh Kabra et al. · 2023
Cited by 1
Robin Goodchild, Richard Munton · 2026
Cited by 0
Massimiliano Maggioni, Giuseppe Turchetti · Springer texts in business and economics · 2024
Cited by 0
El-Sseid, Mohammed, Hadel El-Sseid, Llahm Omar Ben Dalla · 2020
Cited by 0Open access
Judith Dijk, Paul Williams · Palgrave Macmillan UK eBooks · 1990
Early in the planning stage of a new system, special attention must be paid to two elements of the development process: the development methodology, and the testing of the system in a way which will inspire future users with the necessary confidence in it.
Cited by 0
James A. Durr · 2008
Cited by 1
Ralph R. Pawlak · 2016
Cited by 0
Froehling, Kryštof · Brno University of Technology Digital Library (Brno University of Technology) · 2018
Bakalářská práce se zabývá vývojem videoher a vším potřebným k vytvoření úspěšné videohry. První část práce rozlišuje všechny různé role vývojářského týmu a jejich souvislosti. Druhá část analyzuje časovou osu a cíle různých fází vývoje videohry a zároveň hodnotí pozitiva a negativa práce s vydavatelem. Brány v úvahu jsou také certifikační a hodnotící procesy. Třetí a poslední část nabízí pohled do zákulisí vývoje videoher prostřednictvím rozhovoru s herním vývojářem.
Cited by 0