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About 10,000 papers for “Structure function”
Barry D. Solomon · Edward Elgar Publishing eBooks · 2023
This comprehensive Dictionary brings together an extensive range of definitive terms in ecological economics. Assembling contributions from distinguished scholars, it provides an intellectual map to this evolving subject ranging from the practical to the philosophical.
Cited by 1
Gurunath Wachche · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · 2016
Cited by 1
Masayasu Kojima, Kenji Kangawa · Physiological Reviews · 2005
Small synthetic molecules called growth hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary. They act through the GHS-R, a G protein-coupled receptor whose ligand has only been discovered recently. Using a reverse pharmacology paradigm with a stable cell line expressing GHS-R, we purified an endogenous ligand for GHS-R from rat stomach and named it "ghrelin," after a word root ("ghre") in Proto-Indo-European languages meaning "grow." Ghrelin is a peptide hormone in which the third amino acid, usually a serine but in some species a threonine, is modified by a fatty acid; this modification is essential for ghrelin's activity. The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach. In addition, ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus, a region known to control food intake. Ghrelin is orexigenic; it is secreted from the stomach and circulates in the bloodstream under fasting conditions, indicating that it transmits a hunger signal from the periphery to the central nervous system. Taking into account all these activities, ghrelin plays important roles for maintaining GH release and energy homeostasis in vertebrates.
Cited by 2,790
National Cancer Institute · Definitions · 2020
Ope n Pe e r Re v ie w on Qe ios Ope n Pe e r Re v ie
Cited by 1Open access
Shingo Ichimiya, Akira Nakagawara, Yuji Sakuma et al. · Pathology International · 2000
Alteration of the p53 tumor suppressor gene is a common, if not general, observation in human malignant tumors. p73 Is a novel member of the p53 family at chromosome 1p36.3, at which locus frequent defects are seen in many tumors including neuroblastoma. Besides structural similarities, the fact that p73 functions in the regulation of the cell cycle and apoptosis promotes the expansion of the research field concerning p53-associated tumor progression. In this paper, we review the structure and function of p73 as well as the mutational status in various human tumors. In addition, possibilities for new therapeutic applications with p73 for cancer cell control are discussed.
Cited by 27
Ronald van Ree, Akdis, Cezmi A., Agache, Ioana · Pure Amsterdam UMC · 2014
Cited by 2
Candice Thomas, Eric J. Smart · Journal of Cellular and Molecular Medicine · 2008
Studies on the structure and function of caveolae have revealed how this versatile subcellular organelle can influence numerous signalling pathways. This brief review will discuss a few of the key features of caveolae as it relates to signalling and disease processes.
Cited by 157Open access
Vlada B. Urlacher, Katja Koschorreck · Learning materials in biosciences · 2024
Cited by 13
Mary E. Porter, Kenneth A. Johnson · Annual Review of Cell Biology · 1989
Cells organize many of their biochemical reactions in non-membrane compartments. Recent evidence has shown that many of these compartments are liquids that form by phase separation from the cytoplasm. Here we discuss the basic physical concepts necessary ...Read More
Cited by 97
Rositsa Koleva, Barbara A. Conley, Diana Romero et al. · Journal of Biological Chemistry · 2006
Determination of the functional relationship between the transforming growth factor-beta (TGFbeta) receptor proteins endoglin and ALK1 is essential to the understanding of the human vascular disease, hereditary hemorrhagic telangiectasia. TGFbeta1 caused recruitment of ALK1 into a complex with endoglin in human umbilical vein endothelial cells (HUVECs). Therefore, we examined TGFbeta receptor-dependent phosphorylation of endoglin by the constitutively active forms of the TGFbeta type I receptors ALK1, ALK5, and the TGFbeta type II receptor, TbetaRII. Of these receptors, TbetaRII preferentially phosphorylated endoglin on cytosolic domain serine residues Ser(634) and Ser(635). Removal of the carboxyl-terminal tripeptide of endoglin, which comprises a putative PDZ-liganding motif, dramatically increased endoglin serine phosphorylation by all three receptors, suggesting that the PDZ-liganding motif is important for the regulation of endoglin phosphorylation. Constitutively active (ca)ALK1, but not caALK5, phosphorylated endoglin on cytosolic domain threonine residues. caALK1-mediated threonine phosphorylation required prior serine phosphorylation, suggesting a sequential mechanism of endoglin phosphorylation. Wild-type, but not a threonine phosphorylation-defective endoglin mutant blocked cell detachment and the antiproliferative effects of caALK1 expressed in HUVECs. These results suggest that ALK1 is a preferred TGFbeta receptor kinase for endoglin threonine phosphorylation in HUVECs and indicate a role for endoglin phosphorylation in the regulation of endothelial cell adhesion and growth by ALK1.
Cited by 101Open access
Gustavo A. Barisone (152110), Tin Ngo (152123), Martin Tran (152129) et al. · Figshare · 2015
<p>(<b>A</b>) Quantification of cell proliferation (as total number of cells relative to control) of DAOY cells transfected with full-length MXD3 or mutated forms as indicated in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0038508#pone.0038508.s002" target="_blank">Figure S2</a>. MXD3-transfected cells showed 50% reduction of proliferation compared with vector-only (pHM6). Transfection of ΔC and E66Q constructs resulted in similar reduction in proliferation as full-length MXD3. Transfection of the ΔSID, Δbasic, E66D and E66N constructs had no effect on proliferation compared to control (ns, not significant; asterisks, p<0.001; n = 4, one-way ANOVA with Bonferroni’s multiple comparison test). (<b>B</b>) Immunoblot analysis of total protein extracts from DAOY cells transfected with the MXD3 constructs in (B). All constructs used expressed the expected proteins at similar levels. Bottom panel, anti-HA; top panel, anti-β-tubulin used as a load control. Molecular mass markers are indicated on the right.</p>
Cited by 0Open access
Elizabeth Gross · Photosynthesis Research · 1993
Cited by 109
Stein, Gary S., Berezney, Ronald · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · 1996
Cited by 0
Liang Zhang A, Rachel M. Anderson A, Richard M. Crooks A et al. · 2015
This paper summarizes several studies correlating the structure and function of nanoparticle catalysts. Three types of alloy nanoparticles are considered, random alloy,
Cited by 0
Jianyi Yang, Yang Zhang · 2015
Cited by 0
David Geydan, Thomas, Melgarejo, Luz Marina, Melgarejo, Luz Marina · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · 2006
Plasmodesmata are channels that transverse the cell wall and membrane. These specialized and non passive channels act like gates that facilitate and regulate both communication and transportation of molecules such as water, nutrients, metabolites and macromolecules between plant cells. In the last decade a new point of view of plasmodesmata has emerged, and studies have demonstrated that these channels are more complex. In this brief note, we pretend to expose the actual knowledge of plasmodesmata, focusing on their structure and function.
Cited by 0Open access
Gordeliy, V. I. · JuSER (Forschungszentrum Jülich) · 2007
Cited by 0
Gray, Frank D. · Europe PMC (PubMed Central) · 1963
Cited by 0
J. R. Cudell, J. Cugnon, Martine Jaminon et al. · Open Repository and Bibliography (University of Liège) · 2001
Cited by 0
Narasinga Rao, M. S. · CFTRI Institutional Repository · 1985
The rate of hydrolysis of casein, ovalbumin, bovine serum albumin (BSA), arachin (from \ngroundnut, glycinin (from soybean), alpha_globulin (from sesame) and l1s protein from sunflower, \nby trypsin or pepsin has been measured. The rates of hydrolysis have beeo correlated with intrinsic \nviscosity and a-helical content of these proteins. The rates obtained by trypsin hydrolysis correlated \nwell with both intrinsic viscosity and alpha helical content of the proteins whereas the rates obtained with \npepsin correlated with intrinsic viscosity alone; the rates could not be correlated with alpha helical content.
Cited by 0