2013
Summary Numerous interactions between malignant and stromal/inflammatory cells take place within solid human tumours, which are mediated, in part, by the release of signalling proteins called cytokines. In the present study, we have compared the secretion of two important immunomodulatory cytokines, IFN-y and IL-4 by individual, immunophenotyped NK cells freshly isolated from either malignant tumour biopsies, or peripheral blood samples from patients with ductal invasive breast cancer. Due to the marked heterogeneity amongst cells isolated from these clinical samples, we have employed a technique called the reverse haemolytic plaque assay to identify and enumerate cytokine-secreting cells at the single cell level. Our data indicate that NK cells isolated directly from the tumour site secrete more IFN-y and IL4 than NK cells from the blood of the same patients. However, a greater proportion of CD16+ cells from both sources in breast cancer patients secreted IFN-y than of those from the blood of healthy donors. We also show that factors secreted by the human breast cell lines, MCF-7 and MDA-231 PN9, were able to mimic the stimulatory influence of the tumour microenvironment on secretory activity of NK cells. Natural killer (NK) cells can be defined on the basis of their ability to lyse certain tumour cells in a manner which is not dependent upon the expression of MHC molecules. In man,
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I. L. Crighton, M. Dowsett, A. Lalp et al. · 1989
Use of luteinising hormone-releasing hormone agonist (leuprorelin) in advanced post-menopausal breast cancer: clinical and endocrine effects
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N. Mino-miyagawa, Y. Kimura, K. Hamamoto · 2013
An immunoradiometric assay of tumour-antigen 4 (TA-4): a comparison with conventional radioimmunoassay
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Maximilien Gourdin, Anne-Frédérique Naviaux, Pascal Janne · Bulletin du Cancer · 2021
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Mhairi Donald · Dialnet (Universidad de la Rioja) · 2014
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Franz J. Ingelfinger · New England Journal of Medicine · 1975
HERE IS A SPECIAL HEALTH MESSAGERED MAY MEAN DEAD FOR......................YOU OR YOUR LOVED ONESWith scare tactics as blatantly callous as these a Sioux City, Iowa, firm is frightening shoppers into buying a product called "Homaganized Bakon" — exact composition unrevealed except that it contains no nitrites or nitrates.The "Special Health Message," apparently distributed in stores and also displayed on TV states,Most all sliced bacon contains a color additive listed on the package as nitrate or nitrite. This chemical causes the red meat portion of the bacon to assume a brighter than normal, red color that seems . . .
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Kilgore, Alson R. · PubMed Central · 1928
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Caressa Hui, J.R.M. Baclay, Kimberly Liu et al. · International Journal of Radiation Oncology*Biology*Physics · 2021
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Schinz Hr · PubMed · 1954
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Mamsau Ngoma, Philippe Autier · ecancermedicalscience · 2019
Sub-Saharan countries still have a long way to go in controlling the high burden of cervical cancer. Effective prevention methods exist, such as HPV vaccination and screening, but their affordability and implementation remain challenging for most of these countries. Despite that, there is still light on the horizon, as the cost of HPV vaccines has been steadily decreasing and most African countries are using the more cost-effective methods of cervical cancer screening.
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National Cancer Registry Ireland (NCRI) · Lenus, The Irish Health Repository (Dr Steevens Hospital Library) · 2017
In the period 2013-2015, invasive cancer of the cervix uteri \n(ICD10: C53) accounted for just over 1% of all invasive cancers \n(excluding non-melanoma skin cancer) in Ireland, with an average \nof 262 cases diagnosed per year. The age-standardised incidence \nrate (ASIR) for this period was 10.7 per 100,000 per year (1976 \nEuropean Standard Population). \nIn addition, an annual average of 2,890 cases of carcinoma in-situ \nof the cervix, ICD10: D061 (mainly consisting of cervical \nintraepithelial neoplasia 3, CIN3), were diagnosed in Ireland \nduring the same period with an ASIR 119 per 100,000.
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Rubsamen · PubMed · 1953
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Andrew J. Simpson, O. L. Caballero, Achim Jungbluth et al. · 2016
(PMID: 15138364) 1. Gurchot C. The trophoblast theory of cancer (John Beard, 1857-1924) revisited. Oncology 1975; 31: 310-333. (PMID: 1107920)
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Yawei Zhang · Encyclopedia of Global Health · 2008
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Na Kyung Lee, Hong Sung Kim · Journal of Experimental & Biomedical Sciences/Biomedical Science Letters · 2017
It has well reported that host immune system is closely related to cancer growth and eradication. Among cancer immunotherapy, cancer vaccine is focused on this review. Cancer vaccine is using host immune system against various tumor antigens to treat cancer. We discuss the classification and characteristics of the preventive vaccine, therapeutic vaccine and combination cancer immunotherapy.
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Takae Brewer, Rebekah Moore, Joanne Ngeow et al. · Elsevier eBooks · 2024
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Public Health · 1928
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Harlan P. Jones, Yi-chong Wang, Beau Aldridge et al. · 2007
responses against tumor, has traditionally been carried out using collected and expression of CD80 an determined by flow cyto Downloaded fro on May 11, 2016. © 2008 American Assoccancerimmunolres.aacrjournals.org m d CD86 on the surface of B metry. As can be seen in relationship between higher levels of circulating B cells and tumor resistance, and also demonstrating that depletion of B cells correlated with increased lung tumor metastasis in a similar manner to that of NK cells (3, 4). Thus, the known complexities of tumor immune responses lend credence for investigations that may explain these conflicts. Assessment of immune function, particularly cytolytic Expression of CD80 and CD86 by lung and spleen B cells in response to MADB106 tumor Figure 1 and Figure 2 show the expression of CD80 and CD86 molecules on the surface of B cells (CD45RA+) as the result of in vitro incubation with MADB106 tumor cells for varying periods of time. At the end of the incubation period, lymphocytes were supported by CD4+ adaptive immune responses have been shown to foster tumor survival. For example, Qin et al. (2) documented the negative impact of B cells on tumor resistance. Recently, using two NK-sensitive in vivo experimental rat tumor models, we found B cells participate in the defense against tumor development in the lung by demonstrating a direct antitumor activity in the context of the tumor's microenvironment and confirm a potential role for B cells in supportive lung antitumor responses. Resultswww.cancercells obtained from either spleen or blood; this apparently is cells was 080105 Article Lung and splenic B cells facilitate diverse effects on in vitro measures of antitumor immune responses
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Lloyd J. Old · 2007
cytotrophoblasts are CT+, and there is a characteristic temporal 2. What functions do CT/CP gene products have in cancer? e many of the cardinal eristic of gametogenesis/p Downloaded fro on April 8, 2016. © 2007 American Assoccancerimmunolres.aacrjournals.org m features of cancer are also lacentation, e.g. migration, adult ovary, oocytes are rarely CT+, whereas ooblasts in fetal ovary express CT antigens. An extensive analysis of CT antigen expression throughout placental life has recently been published in Cancer Immunity (10). Both syncytiotrophoblasts and account for the anomalous appearance of TL (thymus/leuke-mia) antigens in mouse leukemia and the activation of murine leukemia viruses in mouse tumors (17), two well-studied parallels to CT activation in human cancer.CT-expressing cell type, with little or no expression in subsequent stages of spermatogenesis. Exceptions are CT genes such as SCP-1, which codes for a meiotic protein, and OY-TES-1, coding for the acrosomal binding protein of spermatocytes. In gens. However, the question is what initiates this process of hypomethylation/demethylation in cancer. We can also ask what other genes or gene programs relevant to cancer are brought to life in this way? A similar mechanism may www.cancerexpression pattern for each CT antigen. In the case of cancer, both mRNA and immunohistochemical analysis show CT Becaus charact071019 Editor's View Cancer is a somatic cell pregnancy
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Gert Riethmüller · 2012
IgG4 molecules could later be demonstrated in vivo with somatostatin in brain and pituitary. The influence of that report be underestimated: it se pecific monoclonals.t off a string of papers on beekeepers who were chronically exposed to phospholipase of bee venom (PLA2). These full-size IgG4 antibodies were “functionally monovalent, ” i.e., they blocked other PLA2 antibodies (5). The antibodies had exchanged Fab arms and consisted of two heavy and light chain pairs, each one derived from a different IgG antibody, as was only later discovered. The stochastic nature of the posttranslational formation of bispecific quadroma, an allusion to the four genomes in the final hyperploid cell (12). Because of the motley assortment of various H and L chains in the quadroma supernatant, the yield of the one desired bispecific pair of H/L chains was extremely low. Following the Lloyd Old trail, Milstein and Cuello applied the isolated anti-somatostatin x anti-peroxidase bispecific antibody for a one-step electron microscopic detection of in the 1940s because of its peculiar blocking activity on other antibodies; its true nature, however, had remained completely unknown. Part of the mystery was solved when Rob C. Aalberse and co-workers found elevated IgG4 antibodies in sera of introduced by Martin Glennie and co-workers shortly thereafter (11). Milstein himself had entered the bispecific arena two years before Paulus with the hybrid hybridoma approach, later called recombinant IgG4 antibodies against defined allergens; excess irrelevant IgG4 prevented the formation of hybrid antibodies can hardly various bis120112 Symmetry breaking: bispecific antibodies, the beginnings, and 50 years on
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