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About 10,000 papers for “Cell”

Cell–cell and cell–matrix interactions

Kris A. DeMali, Josephine C. Adams · Molecular Biology of the Cell · 2012

ing.Data were presented on a novel proteolytic processing of talin that is associated with its recruitment and function in cadherinmediated adhesions.

Cited by 3Open access

Cell-cell contacts specify cell fate

Beverly A. Purnell · Science · 2020

Developmental Biology Ascidians, or sea squirts, are marine invertebrate filter feeders with highly reproducible cellular events and invariant embryonic cell lineages. Guignard et al. studied the ascidian embryo to address the determinants of this cellular reproducibility. They introduce computational methods for the robust and automated segmentation, tracking, and analysis of whole-cell behaviors in high-throughput light-sheet microscopy datasets. This work shows that cell induction can be controlled by the contact area among cells. The range of cell signaling is proposed to set the scale at which animal embryonic reproducibility is observed. A high level of reproducibility of embryonic geometries may also counter-intuitively lift constraints on genome evolution, thereby contributing to the rapid molecular evolution observed in ascidians. Science , this issue p. [eaar5663][1] [1]: /lookup/doi/10.1126/science.aar5663

Cited by 0

VIRUS-CELL AND CELL-CELL FUSION

Lorraine D. Hernandez, Lucas R. Hoffman, Tyra G. Wolfsberg et al. · Annual Review of Cell and Developmental Biology · 1996

Significant progress has been made in elucidating the mechanisms of viral membrane fusion proteins; both those that function at low, as well as those that function at neutral, pH. For many viral fusion proteins evidence now suggests that a triggered conformational change that exposes a previously cryptic fusion peptide, along with a rearrangement of the fusion protein oligomer, allows the fusion peptide to gain access to the target bilayer and thus initiate the fusion reaction. Although the topologically equivalent process of cell-cell fusion is less well understood, several cell surface proteins, including members of the newly described ADAM gene family, have emerged as candidate adhesion/fusion proteins.

Cited by 562

Cell–cell and cell–matrix interactions

Taru Muranen · Molecular Biology of the Cell · 2013

In this year's annual ASCB Meeting Minisymposium on Cell-Cell and Cell-Matrix Interactions, new data were presented on several aspects of the biology of cell adhesions.The role of cell adhesions in cancer was the topic of three of the talks, two of which were focused on identifying how invasion is affected by cell-matrix and cell-cell adhesions.Yasmin Moshfegh from Louis Hodgson's lab (Albert Einstein College of Medicine) presented data showing a role for Rac1 in invadopodia formation, one of the initial steps in tumor cell invasion.The data showed that Rac1 suppresses invadopodia formation, and by using a fluorescence resonance energy transfer (FRET)-based Rac biosensor, the researchers showed that Rac1 activity is suppressed at sites of invadopodia formation.They further linked this to Rac1-mediated activation of PAK1, which in turn led to cortactin phosphorylation and invadopodia disassembly.Thomas Marshall (winner of the MBoC Paper of the Year Award) from Jody Rosenblatt's lab (Huntsman Cancer Institute) presented data on how APC (adenomatous polyposis coli) protein regulates the directionality of cell extrusion and how this could contribute to tumor cell metastasis in colon cancer, in which APC is frequently mutated.Cells with normal APC mainly extrude to the apical side of the tissue, whereas mutant APC reverses this directionality.The

Cited by 1

Cell–cell and cell–matrix interactions

Sally Horne‐Badovinac · Molecular Biology of the Cell · 2014

Talks at the "Cell-Cell/Cell-Matrix Interactions and Intracellular Signaling" Minisymposium drew on a wide range of experimental systems and approaches to explore how intracellular interactions produce complex cell shapes, and how cells interact with their neighbors and the extracellular matrix (ECM).

Cited by 8

Cell-cell contact suppresses cell death.

Qi Wei (198826), Venkatesh Hariharan (198827), Hayden Huang (13274) · Figshare · 2015

<p>(<b>A</b>) Percentage of cells undergoing apoptosis analyzed at zero, one and two days post treatments for cells left as untreated control (C group), treated with dispase and suspended as cell sheets (D group), or trypsinized and suspended as single cells (T group). Trypsinized cells, lacking both cell-substrate and cell-cell contact, exhibited significantly increased apoptosis after one day post treatment. (<b>B</b>) The general caspase inhibitor Z-VAD-FMK (ZVAD) significantly reduced apoptosis in trypsinized single cells. Keratinocytes were grouped into three broad groups: untreated controls (C group, lane 1–3), dispase-lifted and suspended as sheets for one day (D group, lane 4–6), and trypsinized and suspended as single cells for one day (T group, lane 7–9). DMSO was used as a vehicle control. ** p<0.01.</p>

Cited by 0Open access

Cell–Cell Interactions

2001

Abstract The book comprises ten chapters written by experts in the field on cell-cell interactions and their role in biology and medicine. Cell-cell interactions are the means by which cells are able to communicate, transfer information, develop spatial awareness and coordinate their differentiation. The ten areas have been selected for their breadth and relevance to modern research scientists where cell-cell interactions have been shown to play a critical role in biological processes. Chapters include methodologies for specialised cell types (keratinocytes, leukocytes, neurons, endothelial cells), specialised domains of membrane contact (adhesion molecules, gap junctions, tight junctions), different developmental models (Drosophila, Xenopus, mouse) and, for mammalian development, distinct stages of medical importance (oocyte-granulosa cells; preimplantation embryos; implantation). Throughout, molecular, cellular, biochemical and physiological protocols are provided in comprehensive detail to help the reader develop new skills and understanding.

Cited by 6

Cell-cell binding.

Sanna Koskiniemi (155015), Fernando Garza-Sánchez (487130), Natasha Edman (704520) et al. · Figshare · 2015

<p>CDI<sup>+</sup> (Bt81) and CDI<sup>–</sup> (wild-type <i>B</i>. <i>thailandensis</i>) cells were labeled with GFP and mixed with the indicated DsRed-labeled target cells, then analyzed by flow cytometry to detect and quantify cell-cell aggregates. Binding was normalized to 1.0 for the interaction between Bt81 and wild-type <i>B</i>. <i>thailandensis</i> cells. Sample values that were statistically different from one another are shown by bars; ** = p < 0.01, and *** = p < 0.001 (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120265#pone.0120265.g001" target="_blank">Fig. 1</a>). We then tested the three CDI<sup>R</sup> target strains and found that ΔBTH_I0986 targets interacted poorly with inhibitor cells, similar to the level observed with CDI<sup>–</sup> mock inhibitors (Fig. 6). In contrast, the ΔBTH_II0599 mutant showed wild-type binding levels, and ΔBTH_I0359 targets showed increased binding to inhibitor cells (Fig. 6). Together, these results suggest that mutations in BTH_I0986 confer CDI<sup>R</sup> by altering the cell surface to prevent stable associations with CDI<sub>II</sub><sup>Bp1026b</sup> inhibitor cells.</p>

Cited by 0Open access

Cell-Cell Channels

F. Baluska, D. Volkmann, PW Barlow · Explore Bristol Research · 2006

Cited by 0

Cell Stem Cell

M. Kanatsu-Shinohara, M. Takehashi, S. Takashima et al. · MPG.PuRe (Max Planck Society) · 2008

Cited by 0

Cell Stem Cell

A. O'Loghlen, A. Munoz-Cabello, A. Gaspar-Maia et al. · MPG.PuRe (Max Planck Society) · 2012

Cited by 0

Cell-cell interaction.

Yousef Jamali (218858), Mohammad Azimi (343458), Mohammad R. K. Mofrad (218868) · Figshare · 2015

<p>Each cell can interact with another cell and substrate in two methods, adhesion and/or repulsive forces due to elasticity, as shown in Eq. (11). a) In this model, all points located on the cell membrane serve as potential sites of cell-cell connections. Each two points from different cells or cell-substrates are connected via a Voigt subunit, once they are closer than a determined value of . The adhesion subunit parameters between two cells are a function of these parameters, for more detail see Eq. (12). b) The repulsive force acts as a short range force. It is a passive force resulting from the elastic interaction with neighboring cells and acts on each point of the cell, when the distance to the other cell points or substrate is less than . The magnitude of the repulsive force is a function of the distance of two surfaces (Eq. (13)) and its direction is perpendicular to the membrane, pointing inward to the inner cell.</p>

Cited by 0Open access