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About 10,000 papers for “DNA replication”

DNA Replication & DNA Replication Stress

Thanos D. Halazonetis · ACS in focus · 2021

Abnormal DNA replication is the primary way that cancer develops in mammals; therefore, a deep understanding of the way replication works for healthy cells will enhance our ability to eradicate problematic replication pathways. The same rapid advances in technology within the last ten to twenty years that have allowed us to understand DNA replication better have also led and will lead to new cancer therapies. In recent years, our understanding of the complexity of DNA replication has advanced tremendously. This e-book distills the bulk of the published studies in DNA replication with an intentional focus on eukaryotes, specifically, budding yeast and mammals. An important feature of this e-book is the incorporated images and figures. Being able to clearly visualize protein and enzymatic processes is central to understanding them. Therefore, we have incorporated images of the three-dimensional structures of the proteins that mediate DNA replication, stepwise guides to simplify the complex nature of the replication process, and cryo-EM images for different proteins and protein–DNA complexes to reveal their structural components. We hope to have provided readers with both fundamentals and cutting-edge information so that they may think about the biology of DNA replication and contribute to the body of knowledge in the field.

Cited by 0

DNA Replication

National Human Genome Research Institute (NHGRI) · Definitions · 2019

Ope n Pe e r Re v ie w on Qe ios

Cited by 0Open access

DNA replication

Peter C. van der Vliet · Current Opinion in Cell Biology · 1989

Cited by 6

DNA Replication

National Cancer Institute · Definitions · 2020

The process by which the two strands of a DNA double helix separate, allowing each strand to act as a template for the synthesis of a complementary strand by specific base pairing. Includes autonomous but not virus replication.

Cited by 0Open access

DNA Replication

NTUR (臺灣機構典藏) · 2006

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DNA replication

Nancy L. Craig, Rachel Green, Carol W. Greider et al. · Oxford University Press eBooks · 2021

This chapter evaluates DNA replication, which occurs in three distinct phases: initiation, elongation, and termination. Initiation of replication in bacteria occurs at a unique chromosomal location called an origin, which is recognized by specific proteins. Initiation of replication in eukaryotes, in contrast, usually occurs stochastically at sites marked in the genome by binding of the pre-replication complex. New DNA strands are initiated by RNA or combined RNA and DNA primers, which are synthesized by primase in bacteria and the polymerase α-primase complex in eukaryotes. After their initial synthesis, the primers are then elongated by the replicative DNA polymerase. The termination of replication occurs when two replication forks traveling in opposite directions meet. The chapter then looks at the regulation of the initiation of DNA replication, the end-replication problem, and the replication of chromatin.

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DNA replication

Yeast · 1988

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DNA replication

Campbell, Judith L.

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DNA replication

Akira ISHIHAMA · Seibutsu Butsuri · 1978

This volume provides critical evaluations of current research on DNA synthesis in vitro as well as details of up-to-date findings on the isolation of small DNA fragments capable of self-replication. The research reflects the wide-spread intereat generated by recent advances in the cloning of certain plasmids carrying replication origins.In this special issue on DNA replication, the following articles are included:I. DNA synthesis in vitro(1) K. Arai, N. Arai (Department of Biochemistry, Stanford University)Studies on DNA replication in cell-free systems from Escherichia coli.(2) J. Ikeda (Department of Developmental Biology and Cancer, Albert Einstein College of Medicine)In vitro synthesis of ΦX174 DNA and ΦXRFI DNA.II. Minimum unit of self-replicating DNA(1) A. Oka (Institute for Chemical Research, Kyoto University)DNA regions essential for replication of colicin E1 plasmid.(2) S. Yasuda (National Institute of Genetics)Cloning of replication regions of various replicons.(3) S. Hiraga, T. Miki (Institute for Virus Research, Kyoto University)Plasmids carrying the replication origin of the becterial chromosome.

Cited by 0Open access