Bezugla, Katya, '18 · DigitalCommons-IMSA (Illinois Mathematics and Science Academy) · 2017
"The fish doesn’t care how long the rain patters, how it splashes against its door. For days and months, the drops have been replacing more of its world, but the fish doesn’t care. Perhaps this is because just like the water, the fish is changing, every cell replaced by a new one."\nExcerpt from Cell Memory
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2008
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Bezugla, Katya, '18 · DigitalCommons-IMSA (Illinois Mathematics and Science Academy) · 2017
"The fish doesn’t care how long the rain patters, how it splashes against its door. For days and months, the drops have been replacing more of its world, but the fish doesn’t care. Perhaps this is because just like the water, the fish is changing, every cell replaced by a new one." Excerpt from Cell Memory
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Encyclopedic Dictionary of Genetics, Genomics and Proteomics · 2004
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Jan W. Gooch · 2011
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Ronald Lee, Johnson M. S, Electrical Engineering et al. · 1966
Abstract approved Redacted for privacy (Major professor) The operation of a tunnel-diode delay-line memory cell is examined in some detail, and a digital computer program which approximately simulates the operation of this memory cell is devel-oped. The data from the computer simulation is compared with the available experimental data and found to agree very closely for clock frequencies up to 100 megahertz. The computer simulation should be accurate at higher frequencies, but limitations in the experimental system preclude the necessary verification. The simulation data, augmented by experimental data, is shown to be useful in answering questions concerning the relative resistance levels of the various components of the circuit, the most desirable tunnel-diode specifications, and the proper timing and termination of the pulses on the delay line. The computer simulationhas in this way added to the previous understanding of the operation of the memory cell, and it has opened the door to further analysis of this and other related tunnel-diode circuits.
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Hans-Werner Vohr · 2015
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Richard Dutton, Linda M. Bradley, Susan L. Swain · Annual Review of Immunology · 1998
Immunological memory can be defined as the faster and stronger response of an animal that follows reexposure to the same antigen. By this definition, it is an operational property of the whole animal or the immune system. Memory cells express a different pattern of cell surface markers, and they respond in several ways that are functionally different from those of naive cells. Murine memory cells are CD44 high and low in the expression of activation markers such as CD25 (IL-2R), whereas human memory cells are CD45RA-, CD45RO+. In contrast to naive cells, memory cells secrete a full range of T cell cytokines and can be polarized to secrete particular restricted patterns of secretion for both CD4 and CD8 T cells. The requirements for the activation of memory cells for proliferation and cytokine production are not quite as strict as those of naive cells, but costimulation in the broad sense is required for optimum responses and for responses to suboptimum antigen concentrations. It would appear that memory cells can persist in the absence of antigenic stimulation and persist as nondividing cells. Reencounter with the same antigen can expand the population to a new, stable, higher level and generate a separate population of CD44 high effectors that may be required for protection, while competition from other antigens can drive it down to a lower stable level. It is unclear how or where memory cells arise, but once generated they have different pathways of recirculation and homing.
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SpringerReference · 2011
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Jonathan Sprent, Charles D. Surh · Annual Review of Immunology · 2002
Typical immune responses lead to prominent clonal expansion of antigen-specific T and B cells followed by differentiation into effector cells. Most effector cells die at the end of the immune response but some of these cells survive and form long-lived memory cells. The factors controlling the formation and survival of memory T cells are reviewed.
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James Sherley · The biomedical & life sciences collection. · 2007
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Joyce T. Tan, Charles D. Surh · Current topics in microbiology and immunology · 2006
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Thierry Defrance, Morgan Taillardet, Laurent Genestier · Current Opinion in Immunology · 2011
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2024
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Rosenblum, MD, Way, SS, Abbas, AK · eScholarship (California Digital Library) · 2015
© 2015 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. Memory for antigen is a defining feature of adaptive immunity. Antigen-specific lymphocyte populations show an increase in number and function after antigen encounter and more rapidly re-expand upon subsequent antigen exposure. Studies of immune memory have primarily focused on effector B cells and T cells with microbial specificity, using primeâchallenge models of infection. However, recent work has also identified persistently expanded populations of antigen-specific regulatory T cells that protect against aberrant immune responses. In this Review, we consider the parallels between memory effector T cells and memory regulatory T cells, along with the functional implications of regulatory memory in autoimmunity, antimicrobial host defence and maternalâfetal tolerance. In addition, we discuss emerging evidence for regulatory T cell memory in humans and key unanswered questions in this rapidly evolving field.
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Peter C. L. Beverley · Current topics in microbiology and immunology · 1990
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Rolf M. Zinkernagel · Current topics in microbiology and immunology · 1990
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Silke Paust, Ulrich H. von Andrian · Nature Immunology · 2011
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Vandana Kalia, Rafi Ahmed, Surojit Sarkar · Elsevier eBooks · 2025
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Su-Hwa Lee (3517232), Ki-Back Chu (6032003), Hae-Ji Kang (6889463) et al. · Figshare · 2019
<p>Flow cytometry plots showing the gating strategy to identify memory T cell subsets (A). The CD4<sup>+</sup> and CD8<sup>+</sup> effector memory T cells were separated by CD3<sup>+</sup>, CD4<sup>+</sup>, CD44<sup>+</sup> and CD62L<sup>-</sup> and CD3<sup>+</sup>, CD8<sup>+</sup>, CD44<sup>+</sup> and CD62L<sup>-</sup> staining. Significantly higher level of CD4<sup>+</sup> and CD8<sup>+</sup> effector memory T cell was found in multi-antigen VLPs immunized mice (Multi-antigen Cha) compared to combination VLPs immunized mice (Combination Cha) or naïve challenged mice (Naïve Cha) (B and D, *<i>P</i> < 0.01). The CD4<sup>+</sup> and CD8<sup>+</sup> central memory T cells were separated by CD3<sup>+</sup>, CD4<sup>+</sup>, CD44<sup>+</sup> and CD62L<sup>+</sup> and CD3<sup>+</sup>, CD8<sup>+</sup>, CD44<sup>+</sup> and CD62L<sup>+</sup> staining. There was no significant difference among the mice groups (C).</p>
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