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About 10,000 papers for “Microscopic Colitis”

Microscopic colitis

John R. Stroehlein · Current Treatment Options in Gastroenterology · 2007

Cited by 8

Microscopic colitis.

Jorge Delgado, Bertha Delgado, Alex Fich et al. · PubMed · 2004

Microscopic colitis is an idiopathic chronic inflammatory bowel disease presenting with watery diarrhea. While colonoscopy and radiology findings are normal, the colon shows striking pathologic findings, including lymphocytic colitis and collagenous colitis. The clinical course is usually benign with sustained remission. Recent medical evidence shows that bismuth and budesonide are effective treatments.

Cited by 1

Microscopic Colitis

Constantinos P. Anastassiades, Dawn D. Ferguson · The American Journal of Gastroenterology · 2006

Microscopic colitis is a histologic diagnosis that encompasses two main entities: collagenous and lymphocytic colitis, each with typical pathologic features that occur in endoscopically normal colonic mucosa. However, there are atypical forms of microscopic colitis that may create confusion. We present such a case. A 57-year-old white female with biopsy-proven microscopic colitis on two prior colonoscopic examinations (2000, 2003) developed recurrent symptoms of watery diarrhea, accompanied by a 14-pound weight loss in late 2005. There was no vomiting, arthropathy, visual disturbance, skin lesions, fever or rigors. A third colonoscopy was performed at an outside institution which, by report, showed diffuse mild erythema throughout the colon. Outside colonic biopsies were consistent with microscopic colitis and terminal ileal biopsies showed villous atrophy and intraepithelial lymphocytosis. The patient's symptoms did not respond to bismuth salicylate. Based on the pathology reports, the non-specific endoscopic findings and the involvement of the terminal ileum, the patient's primary gastroenterologist made the diagnosis of Crohn's disease and initiated treatment with high-dose oral prednisone. The patient's symptoms responded completely. She was then started on budesonide as the prednisone dose was being tapered. The patient was referred to our center for further diagnostic work-up and management recommendations. The colonic biopsies were reviewed by dedicated gastrointestinal pathologists at our institution and an atypical form of microscopic colitis was confirmed. The atypical features included cryptitis, crypt abscesses, focal acute ileitis and intraepithelial lymphocytosis in the terminal ileum. We recommended no further testing and tapering of prednisone along with a 12-week course of budesonide. The patient remains in clinical remission. Biopsies from the terminal ileum of patients with microscopic colitis are more likely to show intraepithelial lymphocytosis, villous atrophy and thickened subepithelial collagen than controls. Inflammatory bowel disease-like histologic features such as cryptitis and crypt abscesses are seen in 30–40% of patients with microscopic colitis. Minimal endoscopic abnormalities and even macroscopic signs of colitis may be present at endoscopic examination.

Cited by 0

Microscopic colitis

Kristin E. Burke, Mauro D’Amato, Siew C. Ng et al. · Nature Reviews Disease Primers · 2021

Cited by 79

Microscopic colitis

Paul Kitchen, Anna Levi, P. Domizio et al. · European Journal of Gastroenterology & Hepatology · 2002

These data confirm that there is wide hospital variation in the diagnosis of microscopic colitis. Furthermore, the small group with the undesignated type may be associated with the use of non-steroidal anti-inflammatory drugs.

Cited by 32

Microscopic Colitis

Vikram Tangri, Nilesh Chande · Journal of Clinical Gastroenterology · 2009

Microscopic colitis (MC) causes chronic diarrhea, abdominal cramping, nausea, and weight loss. Colonic mucosa appears normal on endoscopy; however, biopsies show abnormalities such as intraepithelial lymphocytosis in lymphocytic colitis, and a thickened subepithelial collagen band in collagenous colitis. Epidemiologic data demonstrates that MC is a more common cause of diarrhea than previously shown. Although the etiology of this condition is unclear, certain well-defined risk factors exist. Recently there has been more research on the pathophysiology of MC, and studies on treatment have demonstrated budesonide to be most effective, although other treatments also hold promise.

Cited by 37

Microscopic colitis

Catriona Scicluna, John Schembri, Pierre Ellul · GastroHep · 2020

Microscopic colitis (MC) is an inflammatory bowel disorder characterized by watery nonbloody diarrhoea. It is more common in females and patients over 50 years of age and its pathophysiology is not fully understood. Clinical biomarkers such as faecal calprotectin are usually normal and symptom overlap with functional disorders may lead to hesitation in proceeding with further investigations, thus delaying the diagnosis. Clinical scores can help predict those at risk of MC, as well as monitor disease activity. Histology is essential in diagnosing MC and its two subtypes, lymphocytic and collagenous colitis. However, recent technological advances have enabled us to describe several subtle macroscopic changes that can alert the keen eyed endoscopist to the presence of the condition. Prescribed medications can account for about 10% of MC cases. Other risk factors include concurrent autoimmune disorders and smoking. Thus, the prescription of appropriate medications together with the assessment for any secondary cause, are essential in the management algorithm of this disease.

Cited by 0

Microscopic Colitis

Darrell S. Pardi · 2010

Microscopic colitis is a common cause of chronic watery diarrhea, especially in the elderly. The incidence of this condition is increasing, perhaps due to an association with several commonly used medications. The two subtypes, lymphocytic and collagenous colitis, are only distinguishable histologically. The diagnosis relies on colon biopsies, which show an intra-epithelial lymphocytosis and mixed lamina propria inflammation. In collagenous colitis, the subepithelial collagen band is thickened. The main differential diagnosis is irritable bowel syndrome, and histology is required to distinguish these entities. Several treatment options have been reported, but bismuth subsalicylate and budesonide seem to be the most effective. Many patients require maintenance therapy, but the prognosis is good, with most patients responding to treatment, and no known increased risk of colon cancer or death.

Cited by 0

[Microscopic colitis].

Javier Lizardi-Cervera, Segundo Morán, Eduardo Hinojo-Rivas et al. · PubMed · 2003

The diagnosis of microscopic colitis is made by histopathology findings. The therapeutic response is generally satisfactory.

Cited by 1

Microscopic colitis

Gianluca Ianiro · World Journal of Gastroenterology · 2012

Microscopic colitis may be defined as a clinical syndrome, of unknown etiology, consisting of chronic watery diarrhea, with no alterations in the large bowel at the endoscopic and radiologic evaluation. Therefore, a definitive diagnosis is only possible by histological analysis. The epidemiological impact of this disease has become increasingly clear in the last years, with most data coming from Western countries. Microscopic colitis includes two histological subtypes [collagenous colitis (CC) and lymphocytic colitis (LC)] with no differences in clinical presentation and management. Collagenous colitis is characterized by a thickening of the subepithelial collagen layer that is absent in LC. The main feature of LC is an increase of the density of intra-epithelial lymphocytes in the surface epithelium. A number of pathogenetic theories have been proposed over the years, involving the role of luminal agents, autoimmunity, eosinophils, genetics (human leukocyte antigen), biliary acids, infections, alterations of pericryptal fibroblasts, and drug intake; drugs like ticlopidine, carbamazepine or ranitidine are especially associated with the development of LC, while CC is more frequently linked to cimetidine, non-steroidal antiinflammatory drugs and lansoprazole. Microscopic colitis typically presents as chronic or intermittent watery diarrhea, that may be accompanied by symptoms such as abdominal pain, weight loss and incontinence. Recent evidence has added new pharmacological options for the treatment of microscopic colitis: the role of steroidal therapy, especially oral budesonide, has gained relevance, as well as immunosuppressive agents such as azathioprine and 6-mercaptopurine. The use of anti-tumor necrosis factor-α agents, infliximab and adalimumab, constitutes a new, interesting tool for the treatment of microscopic colitis, but larger, adequately designed studies are needed to confirm existing data.

Cited by 44Open access