Optogenetics
C. Keysers · UvA-DARE (University of Amsterdam) · 2017
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About 10,000 papers for “Optogenetics”
C. Keysers · UvA-DARE (University of Amsterdam) · 2017
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Michael Michaelides, Antonello Bonci · 2022
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Chen, Ching-Jung, Oviedo, Hysell V., Cheng, Katie et al. · CUNY Academic Works (City University of New York) · 2016
Gene insertion of opsin, light-activated cell-membrane channels, into neurons of interest allows researchers to manipulate light to either excite or inhibit neuronal activity to gain a better understanding of brain function and dysfunction, and explore therapeutic applications.
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C. Keysers · UvA-DARE (University of Amsterdam) · 2017
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Sparla, Francesca · AMS Acta - Institutional Research Repository · 2018
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Sachiko Tsuda · Elsevier eBooks · 2020
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Alison Calder · University of Regina Press eBooks · 2022
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Hegemann, Peter 1954- · 2013
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Hegemann, Peter, Sigrist, Stephan · 2013
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Takashi Tokuda, Jun Ohta · The Journal of The Institute of Image Information and Television Engineers · 2012
ChR2 (ChR1 510nm, ChR2 470nm) () H + () ( 1) (NpHR) H + (BR) ChR2 (2) = (470nm) (Na + ) hv 1 (ChR2)
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Baumschlager, Armin · Methods in molecular biology · 2024
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Keysers, C. · Data Archiving and Networked Services (DANS) · 2017
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OAPEN (The OAPEN Foundation) · 2013
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Jens Duebel, Katia Marazova, José‐Alain Sahel · Current Opinion in Ophthalmology · 2015
These recent findings show that novel optogenetic tools and viral vectors for ocular gene delivery are now available providing many opportunities to develop potential optogenetic strategies for vision restoration.
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Library (Trinity College)
Gene insertion of opsin, light-activated cell-membrane channels, into neurons of interest allows researchers to manipulate light to either excite or inhibit neuronal activity to gain a better understanding of brain function and dysfunction, and explore therapeutic applications.
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Sterrer, M. · MPG.PuRe (Max Planck Society) · 2013
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Andre Maia Chagas (3212064), Lucia L. Prieto-Godino (131887), Aristides B. Arrenberg (4255714) et al. · Figshare · 2017
<p><b>A</b>. Experimental configuration suitable for optogenetic stimulation of an individual zebrafish larva suspended in a drop of E3 (Methods). <b>B</b>. Spectrum and peak power of the three light-emitting diodes (LEDs) embedded at each ring position. Spectral filters can be used to limit excitation light reaching the camera (Rosco Supergel No. 19, ‘Fire’). <b>C</b>. Zebrafish larva (3 days postfertilisation [<i>dpf</i>]) expressing ChR2 broadly in neurons (<i>Et(E1b</i>:<i>Gal4)s1101t</i>, <i>Tg(UAS</i>::<i>Cr</i>.<i>ChR2_H134R-mCherry)s1985t</i>, <i>nacre-/-</i>). <b>D</b>. The animal exhibits pectoral fin burst motor patterns upon activation of blue LEDs (cf. <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002702#pbio.2002702.s010" target="_blank">S8 Video</a>). <b>E, F</b>. <i>Drosophila</i> larvae expressing ChR2 in all neurons (elav-GAL4/+; UAS-shibre<sup>ts</sup>; UAS-ChR2/+; UAS-ChR2/+) crawling on ink-stained agar reliably contract when blue LEDs are active. <b>G</b>, <b>H</b>. Proboscis extension reflex (PER) in adult <i>Drosophila</i> expressing CsChrimson in the gustatory circuit (w; +; GMR86A08-GAL4/UAS-CSChrimson; the GMR86A08-GAL4 is part of the Janelia Farm Flightlight collection [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002702#pbio.2002702.ref032" target="_blank">32</a>]; its effect on PER is a personal communication from Olivia Schwarz and Jan Pielage, University of Kaiserslautern, Germany, who observed this phenotype as part of behavioural screen [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2002702#pbio.2002702.ref033" target="_blank">33</a>]) is reliably elicited by activation of red LEDs.</p>
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Chen, Ching-Jung, Oviedo, Hysell V., Cheng, Katie et al. · CUNY Academic Works (City University of New York) · 2016
Gene insertion of opsin, light-activated cell-membrane channels, into neurons of interest allows researchers to manipulate light to either excite or inhibit neuronal activity to gain a better understanding of brain function and dysfunction, and explore therapeutic applications.
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Cambridge University Press eBooks · 2017
Discovered little more than a decade ago, optogenetics - a revolutionary technique combining genetic and optical methods to observe and control the function of neurons - is now a widely used research tool. Optogenetics-driven research has led to insights into Parkinson&apos;s disease and other neurological and psychiatric disorders. With contributions from leaders and innovators from both academia and industry, this volume explores the discovery and application of optogenetics, from the basic science to its potential clinical use. Chapters cover a range of optogenetics applications, including for brain circuits, plasticity, memory, learning, sleep, vision and neurodegenerative and neuropsychiatric diseases. Providing authoritative coverage of the huge potential that optogenetics research carries, this is an ideal resource for researchers and graduate students, as well as for those working in the biotechnology and pharmaceutical industries and in a clinical setting.
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WORLD SCIENTIFIC eBooks · 2023
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