Jérémy Grandhaye (8703483), François Lecompte (829912), Pascal Chartrin (624430) et al. · Figshare · 2021
<p>The F0 parental hens received a diet enriched with 1% grape seed extract (GSE). Hatching chicks from F0 hens were separated in male and female F1-control and F1-GSE. Body composition and reproductive parameters were analysed. Female F1-control and F1-GSE were fertilized by male controls leading to F2 chick production. The development of F2 chicks was analysed until 12 days of age.</p> <p>(PDF)</p>
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Sarah Laxhmi Chellappa (356924), Roland Steiner (356925), Peter Blattner (356926) et al. · Figshare · 2015
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Gabriel Cohen-Aknine (22290555), Raphaël Pionnier (22290558), Denis Mottet (180883) et al. · Figshare · 2025
<div> Motor imagery is the ability to mentally simulate a motor task without actually performing it. Furthermore, pain is an unpleasant sensory experience that involves different dimensions – sensory-discriminative, motivational-affective, and cognitive-evaluative – that are known to interfere with motor imagery. However, it remains unclear which specific pain dimension most significantly impairs motor imagery vividness. This study aims to compare the effects of unpleasant auditory (primarily affective and cognitive) and thermal (primarily sensory) stimuli, which can be assimilated to pain, on discrete and continuous explicit motor imagery sessions. Eighteen healthy participants were exposed to these unpleasant stimuli in addition to a control condition. Participants rated the vividness of their explicit motor imagery after performing full back-and-forth flexion and extension of their wrists in discrete and continuous sessions. Results showed that during discrete explicit motor imagery, only the aversive auditory stimulus significantly reduced motor imagery vividness, whereas thermal pain had no effect. In contrast, motor imagery vividness was preserved during the continuous session. These findings suggest that explicit motor imagery may be more affected by the affective dimension of pain induced by aversive auditory stimuli. The preservation of motor imagery vividness in the continuous session provides insight into the optimization of rehabilitation programs. </div>
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Julie Boisramé-Helms (847992), Grégory Meyer (847993), Su Emmanuelle Degirmenci (847994) et al. · Figshare · 2016
<p>Gastrostomy was performed on day 1 (D1). Rats were then fed with different enteral nutrition products (Peptamen<sup>®</sup> HN–“HN”, Peptamen<sup>®</sup> AF–“AF”, Peptamen<sup>®</sup> AF enriched with arginine–“AFA”) for three days (72 hours) before undergoing peritonitis by cecal ligation and puncture (CLP) or SHAM operation on day 4. Septic shock developed within 18 hours after surgery in the CLP group. Therefore from H18 to H22 after SHAM/CLP surgery, rats were resuscitated using fluid challenge and norepinephrine to target a mean arterial pressure (MAP) value over 100 mmHg. Blood, organs and vessels were collected at the end of the monitoring.</p>
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Maik Gollasch (144991), Yulia Komleva (18780687), Dmitry Tsvetkov (11758346) et al. · Figshare · 2025
<div> <b>Background.</b> Chronic kidney disease (CKD) is a leading risk factor for cardiovascular disease and all-cause mortality among older adults. Mecklenburg-West Pomerania has the highest CKD prevalence in Germany and Europe, however, its impact on frailty prevention strategies in primary care remains poorly understood. The SHIP-AGE/MV-FIT study aims to investigate the role of CKD in frailty incidence. <b>Methods.</b> The SHIP-AGE/MV-FIT cohort is a prospective, longitudinal, population-based observational study targeting individuals 65 years with mGFR >30 mL/min. The cohort will consist of approximately 820 elderly participants who will be monitored over a three-year period. They will undergo a comprehensive, multi-factorial geriatric assessment, along with a structured monitoring and management program aimed at preventing frailty. The program incorporates evidence-based, multi-component care, including physical activity, medication review, nutritional optimization, and fall prevention strategies. <b>Discussion.</b> SHIP-AGE/MV-FIT will clarify CKD’s role in frailty progression and identify mechanisms underlying frailty and pre-frailty. Additionally, the study aims to implement and evaluate multi-component healthcare strategies for frailty and fall prevention, assess patient adherence and quality of life, and explore elderly individuals’ experiences with primary care interventions. By integrating SHIP-AGE data with findings from the SHIP (Study of Health in Pomerania) cohorts in our region, this research will contribute to evidence-based strategies for maintaining health, independence, and well-being in aging populations, particularly in rural primary care settings, such as Mecklenburg-West Pomerania. </div>
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Tahar Rabahi (429947), Patrick Fargier (429948), Ahmad Rifai Sarraj (429949) et al. · Figshare · 2015
<p>Before the start of the experiment the subjects were asked to perform some warm-up jumps, for about 5 minutes, to obtain a correct execution of the movement. The jumps consisted in classical maximal squat vertical jumps (SVJ). The heights of the jumps were measured as described in Material and Methods (section <i>Jump</i>). In a typical block the first 3 jumps were carried without cognitive conditions (to be called baseline jumps, BJ). The following 3 jumps were executed separately after the cognitive stimulus (repeated three times for 10 s before each jump). A rest period of 3 min was observed before a following block.</p>
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Chris A. Vissers, Luís Ferreira Pires, Dick Quartel et al. · Architectural Design · 2016
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Helder V. Ribeiro-Filho (15188347), Gabriel E. Jara (19762506), João V. S. Guerra (19762509) et al. · Figshare · 2024
<div><p>Deep learning methods, trained on the increasing set of available protein 3D structures and sequences, have substantially impacted the protein modeling and design field. These advancements have facilitated the creation of novel proteins, or the optimization of existing ones designed for specific functions, such as binding a target protein. Despite the demonstrated potential of such approaches in designing general protein binders, their application in designing immunotherapeutics remains relatively underexplored. A relevant application is the design of T cell receptors (TCRs). Given the crucial role of T cells in mediating immune responses, redirecting these cells to tumor or infected target cells through the engineering of TCRs has shown promising results in treating diseases, especially cancer. However, the computational design of TCR interactions presents challenges for current physics-based methods, particularly due to the unique natural characteristics of these interfaces, such as low affinity and cross-reactivity. For this reason, in this study, we explored the potential of two structure-based deep learning protein design methods, ProteinMPNN and ESM-IF1, in designing fixed-backbone TCRs for binding target antigenic peptides presented by the MHC through different design scenarios. To evaluate TCR designs, we employed a comprehensive set of sequence- and structure-based metrics, highlighting the benefits of these methods in comparison to classical physics-based design methods and identifying deficiencies for improvement.</p></div>
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Spencer Gardiner (22238328), Peter Dollinger (12635588), Filip Kovacic (125554) et al. · Figshare · 2025
<i>Dashed boxes highlight elements of novelty in this protocol. For each mutation the residues in an ensemble were replaced and evaluated through energy minimization in ground state and tetrahedral conformation. Differences of calculated potential energies were normalized with respect to wild-type ensemble energy differences. Median of differences were reported as ∆E and used to classify variants into favorable or non-favorable candidates. For variants that yielded ∆E values below 1.0 and met other filter criteria, an in vitro experiment was used to verify improved activity. If an activity increase was measured the variant was accepted and served as new start structure.</i>
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Alaa Alghanimy (14797261), Conor Martin (12622147), Lindsay Gallagher (8435382) et al. · Figshare · 2023
<p>Cisterna magna cannulation then intraperitoneal injection of the drug; wait half an hour and start MRI scanning. CM: cisterna magna, IP: intraperitoneal, ADC: apparent diffusion coefficient, and MRI: magnetic resonance imaging.</p>
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Peter Madzík (12667200), Lukáš Falát (12667203) · Figshare · 2022
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Sven Laur · Aaltodoc (Aalto University) · 2008
In this work, we investigate the security of interactive computations. The main emphasis is on the mathematical methodology that is needed to formalise and analyse various security properties. Differently from many classical treatments of secure multi-party computations, we always quantify security in exact terms. Although working with concrete time bounds and success probabilities is technically more demanding, it also has several advantages. As all security guarantees are quantitative, we can always compare different protocol designs. Moreover, these security guarantees also have a clear economical interpretation and it is possible to compare cryptographic and non-cryptographic solutions. The latter is extremely important in practice, since cryptographic techniques are just one possibility to achieve practical security. Also, working with exact bounds makes reasoning errors more apparent, as security proofs are less abstract and it is easier to locate false claims. \n The choice of topics covered in this thesis was guided by two principles. Firstly, we wanted to give a coherent overview of the secure multi-party computation that is based on exact quantification of security guarantees. Secondly, we focused on topics that emerged from the author's own research. In that sense, the thesis generalises many methodological discoveries made by the author. \n As surprising as it may seem, security definitions and proofs mostly utilise principles of hypothesis testing and analysis of stochastic algorithms. Thus, we start our treatment with hypothesis testing and its generalisations. In particular, we show how to quantify various security properties, using security games as tools. Next, we review basic proof techniques and explain how to structure complex proofs so they become easily verifiable. In a nutshell, we describe how to represent a proof as a game tree, where each edge corresponds to an elementary proof step. As a result, one can first verify the overall structure of a proof by looking at the syntactic changes in the game tree and only then verify all individual proof steps corresponding to the edges. \n The remaining part of the thesis is dedicated to various aspects of protocol design. Firstly, we discuss how to formalise various security goals, such as input-privacy, output-consistency and complete security, and how to choose a security goal that is appropriate for a specific setting. Secondly, we also explore alternatives to exact security. More precisely, we analyse connections between exact and asymptotic security models and rigorously formalise a notion of subjective security. Thirdly, we study in which conditions protocols preserve their security guarantees and how to safely combine several protocols. Although composability results are common knowledge, we look at them from a slightly different angle. Namely, it is irrational to design universally composable protocols at any cost; instead, we should design computationally efficient protocols with minimal usage restrictions. Thus, we propose a three-stage design procedure that leads to modular security proofs and minimises usage restrictions.
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Winstein, Keith, Das, Somak, Ma, Joshua et al. · DSpace@MIT (Massachusetts Institute of Technology) · 2014
In fields like data mining and natural language processing, design contests have been successfully used to advance the state of the art. Such contests offer an opportunity to bring the excitement and challenges of protocol design---one of the core intellectual elements of research and practice in networked systems---to a broader group of potential contributors, whose ideas may prove important. Moreover, it may lead to an increase in the number of students, especially undergraduates or those learning via online courses, interested in pursuing a career in the field. We describe the creation of the infrastructure and our experience with a protocol design contest conducted in MIT's graduate Computer Networks class. This contest involved the design and evaluation of a congestion-control protocol for paths traversing cellular wireless networks. One key to the success of a design contest is an unambiguous, measurable objective to compare protocols. In practice, protocol design is the art of trading off conflicting goals with each other, but in this contest, we specified that the goal was to maximize $\log(\mbox{throughput}/\mbox{delay})$. This goal is a good match for applications such as video streaming or videoconferencing that care about high throughput and low interactive delays. Some students produced protocols whose performance was better than published protocols tackling similar goals. Furthermore, the convex hull of the set of all student protocols traced out a tradeoff curve in the throughput-delay space, providing useful insights into the entire space of possible protocols. We found that student protocols diverged in performance between the training and testing traces, indicating that some students had overtrained ("overfitted") their protocols to the training trace. Our conclusion is that, if designed properly, such contests could benefit networking research by making new proposals more easily reproducible and amenable to such "gamification," improve networked systems, and provide an avenue for outreach.
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2016
of a prospective cohort study to assess ie er rs should be equally achievable for all patients, independent overview of published empirical studies outside of Europe van Rosse et al. BMC Health Services Research 2012, 12:450
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Deepinder P. Sidhu · 1982
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Reinhardt, Kimberly · Texas A&M University-Corpus Christi · 2019
This instructional design protocol is an adaption intended provide teacher candidates with a comprehensive model from which to plan and deliver lessons. Designed to be used with teacher candidates and clinical teacher who are enrolled in educator preparation programs.
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Chengsheng Liao (19832217), Zhen Gong (292434), Run Fang (4585858) et al. · Figshare · 2024
<p>(a) Segmentation method according to actual workflow. (b) The “action-delay” beat division method. (c) Universal staining protocol. (d) Generic sub-protocols considering competition mechanisms. (e) Parent protocol running method.</p>
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Alix Barbe (8703480), Namya Mellouk (4794672), Christelle Ramé (89741) et al. · Figshare · 2020
<p>From one to the fourth week of age, 324 female breeder chicks received an <i>ad libitum</i> diet (free access to food), called a starting diet. At week 4, all animals received a restricted diet according to Hendrix Genetics recommendation. From 4 week to 40 week, animals received three different diets: growing (from 4 to 18 week), before laying (from 18 week to 21 week) and laying (from 21 week to 40 week). We performed two experiments according the time of GSE supplementation. In the experiment 1, the animals were divided into three groups: group A (control, n = 92), group B and C supplemented with GSE at 0.5% (n = 80) and 1% (= 80) of the total diet composition, respectively, since the age of 4 weeks until 40 week-old. In the experiment 2, we used two groups of animals: group A (control, n = 92) and group D (supplemented with 1% of GSE since the hatching until 40 week-old, n = 72). For both experiments, eggs were collected during the whole laying period, from 23<sup>th</sup> to 40<sup>th</sup> week. At 26<sup>th</sup> week, the quality of 30 eggs per group was assessed. At 28<sup>th</sup> week, the first Artificial Insemination (AI1) was performed and the fertility parameters were assessed after the hatching. At 33<sup>th</sup> week, the steroidogenesis and ROS level in yolk eggs were assessed, for 30 and 10 egg yolks per group of animals, respectively, and then the second Artificial Insemination (AI2) was performed.</p> <p>(PDF)</p>
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BOH CHEK LIANG, DOMINIC · National University of Singapore · 2004
Master's
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Karel Joineau (21799908), Estelle Harroch (9954914), Mathilde Boussac (9954908) et al. · Figshare · 2025
V: Visit, FR: Foot Reflexology, SM: Sham Massage. (TIFF)
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