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About 10,000 papers for “sensitivity function”

Error sensitivity function catalog

Vetter, J. R., Martin, C. F. · NASA Technical Reports Server (NASA)

PAGE 5.2 Long Arc Multiple Station 9 5.2.1 Orbit Accuracy 9 5.2.2 Residuals 5.2.3 Characteristics of Long Arc Multi-Station Solutions 6.0 Problems in Error Model Recovery 6.1 General 6.2 Short Arc Recovery 6.2.1 Orbit Accuracy 6.2.2 Characteristics of Short Arc Bias Recovery 62 with Bias Adjustments 6.3.1 Orbit Accuracy 6.3.

Cited by 0Open access

Sensitivity and block sensitivity of nested canalyzing function

Yuan Li, John O. Adeyeye · arXiv (Cornell University) · 2012

Based on a recent characterization of nested canalyzing function (NCF), we obtain the formula of the sensitivity of any NCF. Hence we find that any sensitivity of NCF is between $\frac{n+1}{2}$ and $n$. Both lower and upper bounds are tight. We prove that the block sensitivity, hence the $l$-block sensitivity, is same to the sensitivity. It is well known that monotone function also has this property. We eventually find all the functions which are both monotone and nested canalyzing (MNCF). The cardinality of all the MNCF is also provided.

Cited by 3Open access

Sensitivity analysis of executive function.

Qing Yi (495197), Zuhong Liu (4406455), Fei Zhong (409715) et al. · Figshare · 2024

<div><p>Emerging studies have examined the effectiveness of combined exercise and cognitive intervention (combined intervention) on the cognitive function of older adults with MCI, but the conclusions remain disputed. Our study aimed to comprehensively examine the efficacy of the combined intervention on cognitive and physical function in older adults with MCI. PubMed, Cochrane Library, EMBASE, and PsycINFO were retrieved to identify the relevant articles. Twelve eligible studies were included, and the results showed that combined intervention significantly improved global cognition SMD = 0.26, 95% CI [0.14-0.39], <i>p</i><0.0001), executive function (SMD = 0.40, 95% CI [0.25-0.56], <i>p</i> < 0.00001), memory (SMD = 0.30, 95% CI [0.22-0.39], <i>p</i> <0.00001), and gait performance (SMD = 0.32, 95% CI [0.03-0.62], <i>P</i> = 0.03) compared to the control group. Combined intervention significantly improved executive function compared to single exercise intervention while not showing a statistically significant difference compared to single cognitive intervention. Moreover, no significant difference was observed between simultaneously and sequentially combined intervention. The finding indicated that combined intervention is efficacious in improving global cognition and selectively enhancing cognitive domains and physical function in older adults with MCI. More research with robust designs should be conducted, particularly involving comparisons with single interventions and different types of combined interventions.</p></div>

Cited by 0Open access

Myopia and contrast sensitivity function

Shiow‐Wen Liou, Cheng‐Jen Chiu · Current Eye Research · 2001

1. We may suppose that low and medium myopes (groups 1 and 2), who showed normal contrast sensitivity functions, had no retinal dysfunction. 2. For high myopes, contact lens correction could reduce optical defocus and improve contrast sensitivity function in high spatial frequencies. 3. As retinal function disturbances occurred in severe myopes, the diminished contrast sensitivity was not fully compensated by contact lens correction. 4. Loss of contrast sensitivity might be interpreted as evidence for early retinal function disruption before retinal pathological events occur in severe myopes.

Cited by 108

Sensitivity function: Properties and applications

А. С. Антипин, A. I. Golikov, Е.В. Хорошилова · Computational Mathematics and Mathematical Physics · 2011

The sensitivity function induced by a convex programming problem is examined. Its monotonicity, subdifferentiability, and closure properties are analyzed. A relation to the Pareto optimal solution set of the multicriteria convex optimization problem is established. The role of the sensitivity function in systems describing optimization problems is clarified. It is shown that the solution of these systems can often be reduced to the minimization of the sensitivity function on a convex set. Numerical methods for solving such problems are proposed, and their convergence is proved.

Cited by 6

Contrast Sensitivity Function in Nephropathic Cystinosis

Barrett Katz, Ronald B. Melles, Jerry A. Schneider · Archives of Ophthalmology · 1987

Cystinosis is a rare autosomal recessive metabolic disorder in which nonprotein cystine accumulates within most body organs due to a defect in lysosomal cystine transport. The pathognomonic ocular manifestations of cystinosis are the presence of distinctive iridescent crystals within ocular tissue and a pigmentary retinopathy. We measured spatial contrast sensitivity in seven patients with infantile-onset nephropathic cystinosis and compared their contrast sensitivity function with that measured in ten age-matched controls. Spatial contrast sensitivities in the patient group were significantly lower than those in the normal group. Loss of contrast sensitivity in the patients with nephropathic cystinosis was more pronounced at higher spatial frequencies. We speculate that this loss of contrast function is primarily a manifestation of corneal disease, with secondary contributions from retinal changes and central nervous system dysfunction.

Cited by 12

modulates chaperone function and drug sensitivity

Mehdi Mollapour, Shinji Tsutsumi, Yeong Sang Kim et al. · 2016

Copyright: © Mollapour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The molecular chaperone Heat Shock Protein 90 (Hsp90) is essential for the function of various oncoproteins that are vital components of multiple signaling networks regulating cancer cell proliferation, survival, and metastasis. Hsp90 chaperone function is coupled to its ATPase activity, which can be inhibited by natural products such as the ansamycin geldanamycin (GA) and the resorcinol radicicol (RD). These compounds have served as templates for development of numerous natural product Hsp90 inhibitors. More recently, second generation, fully synthetic Hsp90 inhibitors, based on a variety of chemical scaffolds, have also been synthesized. Together, 18 natural product and synthetic Hsp90 inhibitors have entered clinical trial in cancer patients. To successfully develop Hsp90 inhibitors for oncology indications it is important to understand the factors that influence the susceptibility of Hsp90 to these drugs in vivo. We recently reported that Casein Kinase 2 phosphorylates a conserved

Cited by 0

Contrast-sensitivity-function-based clutter metric

Xiuqin Chu · Optical Engineering · 2012

Background clutter can obscure or mimic the desired target and confuse the operator. Thus, the similarity between the background and the target is a typical feature of the background clutter. A clutter metric based on human contrast sensitivity function is proposed. It measures the similarity between the background and the target in the frequency domain, after the differences that cannot be seen by the visual system have been "thrown away" and the visible differences have been weighted according to the sensitivity of the visual system. The correlation between the experimental probability of detection and that predicted by the clutter metric are presented. Experiment results show that the contrast-sensitivity-function-based clutter metric can perform other clutter metrics in open literature in quantifying background clutter.

Cited by 11

Transfer function models and sensitivity analysis

Ajay M. Koshti · 2023

In many situations, real or induced flaws such as tight cracks with known morphology cannot be manufactured in part configuration specimens or in real parts. Typically, fatigue cracks are manufactured in simple geometry specimens such as flat plates, dog-bone shaped flat or round specimens. If a nondestructive evaluation (NDE) technique is required to provide a reliably detectable target flaw size denoted as a<sub>90/95</sub> for induced flaws in real part, then the direct method for qualifying the NDE procedure is to use the appropriate induced flaw specimens and perform probability of detection analysis using these flaws. This can be described as direct POD demonstration testing, which may follow guidelines of MIL-HDBK-1823. This paper considers a case, where induced flaws are not available in part configuration specimens. Therefore, a direct POD demonstration study cannot be undertaken. In such situation, general practice for NDE procedure qualification is to use artificial flaws in simple geometry and part configuration specimens, and induced flaws in the same simple geometry specimens. Signal response data is taken on all sets of artificial and induced flaws. NDE procedure testing on induced flaws in simple geometry specimen is called NDE demonstration testing here. A transfer function NDE procedure qualification method for the forward case calculates predicted induced flaw size for demonstration using a chosen target flaw size. Another transfer function method for the inverse case, calculates the target flaw size using a given demonstration flaw size. The transfer function analysis assumes relationship of artificial flaw signal responses in real parts and simple geometry specimens; and induced flaw responses in simple geometry specimens to induced flaws in real parts. The signal response transfer relationships model should be defined before transfer function models can be devised. Assuming that the signal response transfer relationships model is valid, the forward and inverse case transfer function methods have been devised. Because of lack of signal response data from induced flaws in real part, the 90/95% POD/confidence (P/C) cannot be demonstrated directly. However, the transfer function method may be assessed using simulation to evaluate whether the resulting target flaw size or demonstration flaw size provides adequate confidence to the assumed signal response transfer relationships model. Therefore, the transfer function approach is a risk assessment approach. Both the signal response transfer relationships model and the transfer function model are important in managing risk in results provided by the transfer function NDE technique qualification or assessment. The signal response transfer relationships model needs to be validated with empirical data and then transfer function model needs to be validated for desired P/C on case-by-case basis.

Cited by 2

Genomic context sensitivity of insulator function

André M. Ribeiro-dos-Santos, Megan S. Hogan, Raven D. Luther et al. · Genome Research · 2022

The specificity of interactions between genomic regulatory elements and potential target genes is influenced by the binding of insulator proteins such as CTCF, which can act as potent enhancer blockers when interposed between an enhancer and a promoter in a reporter assay. But not all CTCF sites genome-wide function as insulator elements, depending on cellular and genomic context. To dissect the influence of genomic context on enhancer blocker activity, we integrated reporter constructs with promoter-only, promoter and enhancer, and enhancer blocker configurations at hundreds of thousands of genomic sites using the <i>Sleeping Beauty</i> transposase. Deconvolution of reporter activity by genomic position reveals distinct expression patterns subject to genomic context, including a compartment of enhancer blocker reporter integrations with robust expression. The high density of integration sites permits quantitative delineation of characteristic genomic context sensitivity profiles and their decomposition into sensitivity to both local and distant DNase I hypersensitive sites. Furthermore, using a single-cell expression approach to test the effect of integrated reporters for differential expression of nearby endogenous genes reveals that CTCF insulator elements do not completely abrogate reporter effects on endogenous gene expression. Collectively, our results lend new insight into genomic regulatory compartmentalization and its influence on the determinants of promoter-enhancer specificity.

Cited by 19Open access

Contrast sensitivity-luminance function in aging

Michael E. Sloane, Cynthia Owsley · Annual Meeting Optical Society of America · 1987

We have previously reported (ARVO, 1987) that senile miosis cannot account for age-related deficits in spatial contrast sensitivity over a three-log unit range of luminance. Although the participants were free from significant media opacity, the possibility remains that their deficits could be due to differences in retinal illuminance between young and older observers. If a difference in retinal illuminance accounted for the age differences in contrast sensitivity, functions plotting sensitivity against luminance should be superimposable by a shift parallel to the luminance axis. In the present study we measured spatial contrast sensitivity under a range of luminance levels in young and old adults who were free from identifiable eye disease. Contrast thresholds for sinusoidal gratings (0.5, 2, 4, 8 cycles/deg) were measured over a three-log unit range of luminance (0.1-107 cd/m 2 ), sampled at 0.5-log unit intervals. The contrast sensitivity–luminance functions changed as a function of test spatial frequency for both age groups. The functions at all spatial frequencies were parallel for the two age groups and could be superimposed by a vertical shift along the sensitivity axis and not by a lateral shift along the luminance axis. These data suggest that the age-related deficits in spatial contrast sensitivity are not the simple consequence of reductions in retinal illuminance produced by either senile miosis or increased light absorption by the ocular media.

Cited by 0