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About 10,000 papers for “variable domains”

Engineered Autonomous Human Variable Domains

Johan Nilvebrant, Peter M. Tessier, Sachdev S. Sidhu · Current Pharmaceutical Design · 2016

Recent findings enable the construction of highly diverse libraries enriched in aggregation-resistant variants that are expected to provide binders to diverse antigens. Engineered domain antibodies possess unique advantages in expression, epitope preference and flexibility of formatting over conventional immunoreagents and are a promising class of antibody fragments for biomedical development.

Cited by 32

Unknown or variable domains, inverse problems

Huy Duong Bui, Marc Bonnet · HAL (Le Centre pour la Communication Scientifique Directe) · 1995

Engineering Analysis with Boundary Elements 15(2), special issue (12 articles)

Cited by 3

Directed Mutagenesis of Antibody Variable Domains

Kevin Brady, Benny K. C. Lo · Humana Press eBooks · 2004

The ability to mutate antibodies at the genetic level is a powerful tool in the antibody engineer’s toolbox. Specific properties of these molecules, such as stability, specificity, and in some cases catalysis, can be thoroughly studied using mutagenesis techniques. Harnessed to other techniques such as affinity measurements (see Chapters 23– 25), catalytic assays or biophysical characterization, mutagenesis can reveal the exact atomic mechanisms involved. Mutagenesis also provides the engineer with the ability to incorporate improved functionality into the antigen-binding site.

Cited by 0

Eigenvalues of polyharmonic operators on variable domains

Davide Buoso, Pier Domenico Lamberti · Springer Link (Chiba Institute of Technology)

We consider a class of eigenvalue problems for polyharmonic operators, including Dirichlet and buckling-type eigenvalue problems. We prove an analyticity result for the dependence of the symmetric functions of the eigenvalues upon domain perturbations and compute Hadamard-type formulas for the Frechét differentials. We also consider isovolumetric domain perturbations and characterize the corresponding critical domains for the symmetric functions of the eigenvalues. Finally, we prove that balls are critical domains.

Cited by 50

Computer-Assisted Modeling of Antibody Variable Domains

Oscar Henrique Pereira Ramos · Methods in molecular biology · 2012

Antibody modeling is an interesting option to gain structure-function insights and to allow rational engineering of these molecules in the absence of experimental data. Among a diversity of algorithms, software packages, and specialized Web servers, the protocol described here presents the following main features: (1) nonautomatic modeling process guided by direct application of antibody modeling principles; (2) local generation of molecular models using free software which can be used in most common operational systems; and (3) the resulting model quality is comparable to models generated by Web servers which represent the current standard of antibody modeling. Briefly, hybrid models of heavy- and light-chain variable domains are separately built by grafting segments from homologous templates (framework regions and complementarity-determining regions). Next, hybrid models are mutated to comply with the target's sequence and associated by fitting into a template structure that closely matches the predicted packing angle for the target variable domains. After a few cycles of energy minimization the model can be submitted to CDR-H3 optimization or its quality can be directly assessed.

Cited by 4

Parcel Feature subset selection in variable cost domains

M. J. J. Scott, M. Niranjan, R. W. Prager · OpenGrey (Institut de l'Information Scientifique et Technique) · 1998

The vast majority of classification systems are designed with a single set of features, and optimised to a single specified cost. However, in examples such as medical and financial risk modelling, costs are known to vary subsequent to system design. In this paper, we present a design method for feature selection in the presence of varying costs. Starting from the Wilcoxon nonparametric statistic for the performance of a classification system, we introduce a concept called the maximum realisable receiver operating characteristic (MRROC), and prove a related theorem. A novel criterion for feature selection, based on the area under the MRROC curve, is then introduced. This leads to a framework which we call Parcel. This has the flexibility to use different combinations of features at different operating points on the resulting MRROC curve. Empirical support for each stage in our approach is provided by experiments on real world problems, with Parcel achieving superior results. iv v C...

Cited by 10

Antibody Discovery: Sourcing of Monoclonal Antibody Variable Domains

William R. Strohl · Current Drug Discovery Technologies · 2014

Historically, antibody variable domains for therapeutic antibodies have been sourced primarily from the mouse IgG repertoire, and typically either chimerized or humanized. More recently, human antibodies from transgenic mice producing human IgG, phage display libraries, and directly from human B lymphocytes have been used more broadly as sources of antibody variable domains for therapeutic antibodies. Of the total 36 antibodies approved by major maket regulatory agencies, the variable domain sequences of 26 originate from the mouse. Of these, four are marketed as murine antibodies (of which one is a mouse-rat hybrid IgG antibody), six are mouse-human chimeric antibodies, and 16 are humanized. Ten marketed antibodies have originated from human antibody genes, three isolated from phage libraries of human antibody genes and seven from transgenic mice producing human antibodies. Five antibodies currently in clinical trials have been sourced from camelids, as well as two from non-human primates, one from rat, and one from rabbit. Additional sources of antibody variable domains that may soon find their way into the clinic are potential antibodies from sharks and chickens. Finally, the various methods for retrieval of antibodies from humans, mouse and other sources, including various display technologies and amplification directly from B cells, are described.

Cited by 34

Conserved and variable domains of RNase MRP RNA

Marcela Dávila López, Magnus Alm Rosenblad, Tore Samuelsson · RNA Biology · 2009

Ribonuclease MRP is a eukaryotic ribonucleoprotein complex consisting of one RNA molecule and 7-10 protein subunits. One important function of MRP is to catalyze an endonucleolytic cleavage during processing of rRNA precursors. RNase MRP is evolutionary related to RNase P which is critical for tRNA processing. A large number of MRP RNA sequences that now are available have been used to identify conserved primary and secondary structure features of the molecule. MRP RNA has structural features in common with P RNA such as a conserved catalytic core, but it also has unique features and is characterized by a domain highly variable between species. Information regarding primary and secondary structure features is of interest not only in basic studies of the function of MRP RNA, but also because mutations in the RNA give rise to human genetic diseases such as cartilage-hair hypoplasia.

Cited by 57Open access

MAb SD6 and modelling of D9 variable domains.

Gareth Shimmon (3142221), Abhay Kotecha (395425), Jingshan Ren (395427) et al. · Figshare · 2018

<p>Cartoon depiction showing SD6 variable domains in grey and modelled D9 VH domain in orange and VL domain in blue. The peptide bound to SD6 is shown in red with the side chains for the RGD motif and the L residues at 144 and 148 drawn in stick representation coloured by atom. R/E indicates the position of the first residue of CDR3, which is an R in SD6 and an E in D9. In the FMDV/SD6 complex the R interacts with VP1 D-147 (interactions are represented by yellow broken lines).</p>

Cited by 0Open access

Variable forgetting in preference relations over propositional domains

Université Paul Sabatier · 2008

Representing (and reasoning about) preference relations over combinatorial domains is computationally expensive. We argue that for many problems involving such preferences, it is relevant to simplify them by projecting them on a subset of variables. We investigate several possible definitions, focusing without loss of generality on propositional (binary) variables. We then define the notion of independence of a preference relation from a set of propositional variables. 1

Cited by 0

Variable Forgetting in Preference Relations over Propositional Domains

Philippe Besnard, Jérôme Lang, Pierre Marquis · HAL (Le Centre pour la Communication Scientifique Directe) · 2006

Representing (and reasoning about) preference relations over combinatorial domains is computationally expensive. For many problems involving such preferences, it is relevant to simplify them by projecting them on a subset of variables. We investigate several possible definitions, focusing without loss of generality on propositional (binary) variables.

Cited by 3