article · IEEE Transactions on NanoBioscience · 2005

DNA Microarray Stochastic Model

Cited by 10Abstract and details only

Abstract

A stochastic model of the DNA microarray image pixels is presented. The model includes spot pixel intensity distribution, interpixel correlations and the intensity distribution of background noise. The data is indicative of a small exponential additive noise process and a larger Gaussian fluctuation that scales with spot intensity. Correlations are observed among pixels in the spot and between test and control images. The correlated fluctuations may be attributed to variations across each spot in the amount of DNA placed on the spot during the array fabrication process. The model may be used in gene expression estimation algorithm development, both to test new algorithms through simulation and to develop optimum algorithms. The model should also be easily adapted to new array based technologies in proteomics.

Cite this paper

APA 7

Davies, S., & Seale, D. A. (2005). DNA Microarray Stochastic Model. IEEE Transactions on NanoBioscience, 4(3), 248–254. https://doi.org/10.1109/tnb.2005.853665

MLA 9

Davies, S.W., and Darryl A. Seale. “DNA Microarray Stochastic Model.” IEEE Transactions on NanoBioscience, vol. 4, no. 3, 2005, pp. 248–54, https://doi.org/10.1109/tnb.2005.853665.

Chicago

Davies, S.W., and Darryl A. Seale. 2005. “DNA Microarray Stochastic Model.” IEEE Transactions on NanoBioscience 4 (3): 248–54. https://doi.org/10.1109/tnb.2005.853665.

Harvard

Davies, S. and Seale, D.A. (2005) ‘DNA Microarray Stochastic Model’, IEEE Transactions on NanoBioscience, 4(3), pp. 248–254. Available at: https://doi.org/10.1109/tnb.2005.853665.

BibTeX

@article{davies2005microarray,
  title = {{DNA Microarray Stochastic Model}},
  author = {Davies, S.W. and Seale, Darryl A.},
  journal = {IEEE Transactions on NanoBioscience},
  volume = {4},
  number = {3},
  pages = {248--254},
  year = {2005},
  doi = {10.1109/tnb.2005.853665}
}

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