review · Arteriosclerosis Thrombosis and Vascular Biology · 2024
Radiation-Induced Macrovessel/Microvessel Disease
Jun‐ichi Abe, Bryan G. Allen, Andreas Beyer, David Lewandowski, Kranti A. Mapuskar, Vikram Subramanian, Michelle R. Tamplin, Isabella M. Grumbach
Cited by 14Open access
Abstract
Radiation therapy (RT) is a cornerstone in cancer treatment (used in 50% of cases), yet challenges persist because damage to normal tissue through direct impact of radiation or bystander effects is inevitable. Injury of macrovessels by RT manifests as obstructive disease, which is akin to atherosclerotic disease. Historically observed in coronary arteries of patients treated for breast cancer and lymphoma, it also affects patients receiving contemporary therapy for lung and chest cancers. Moreover, radiation at various sites can lead to peripheral vascular disease. An aspect of radiation-induced injury that has received little attention is microvascular injury, which typically results from damage to the endothelium and is considered the primary driver of RT-induced toxicity in the skin, kidney, and brain. This review delves into the clinical manifestations of RT-induced vascular disease, signaling pathways, cellular targets affected by radiation injury, and preclinical models of RT-induced vascular injury. The goal is to inspire the development of innovative strategies to prevent RT-related cardiovascular disease.
Cite this paper
Abe, J., Allen, B. G., Beyer, A., Lewandowski, D., Mapuskar, K. A., Subramanian, V., Tamplin, M. R., & Grumbach, I. M. (2024). Radiation-Induced Macrovessel/Microvessel Disease. Arteriosclerosis Thrombosis and Vascular Biology, 44(12), 2407–2415. https://doi.org/10.1161/atvbaha.124.319866
Abe, Jun‐ichi, et al. “Radiation-Induced Macrovessel/Microvessel Disease.” Arteriosclerosis Thrombosis and Vascular Biology, vol. 44, no. 12, 2024, pp. 2407–15, https://doi.org/10.1161/atvbaha.124.319866.
Abe, Jun‐ichi, Bryan G. Allen, Andreas Beyer, David Lewandowski, Kranti A. Mapuskar, Vikram Subramanian, Michelle R. Tamplin, and Isabella M. Grumbach. 2024. “Radiation-Induced Macrovessel/Microvessel Disease.” Arteriosclerosis Thrombosis and Vascular Biology 44 (12): 2407–15. https://doi.org/10.1161/atvbaha.124.319866.
Abe, J. et al. (2024) ‘Radiation-Induced Macrovessel/Microvessel Disease’, Arteriosclerosis Thrombosis and Vascular Biology, 44(12), pp. 2407–2415. Available at: https://doi.org/10.1161/atvbaha.124.319866.
@article{abe2024radiation,
title = {{Radiation-Induced Macrovessel/Microvessel Disease}},
author = {Abe, Jun‐ichi and Allen, Bryan G. and Beyer, Andreas and Lewandowski, David and Mapuskar, Kranti A. and Subramanian, Vikram and Tamplin, Michelle R. and Grumbach, Isabella M.},
journal = {Arteriosclerosis Thrombosis and Vascular Biology},
volume = {44},
number = {12},
pages = {2407--2415},
year = {2024},
doi = {10.1161/atvbaha.124.319866}
}Made from the index record. Check names, capitalisation and page numbers against the paper. Need another style? AI for Research has over 10,000.