Skip to content
Free planNo credit card requiredStart writing
AI for Research home
AI for Research home
Dashboard
Sign inGet started

Search 250 million research papers

Read the abstract, see who wrote it and who cites it, and get the citation in APA, MLA, Chicago or Harvard.

About 10,000 papers for “Structure function”

TNF: Structure and Function

Grams, Raymond W., II, McClellan, Dr. David A. · ScholarsArchive (Brigham Young University) · 2013

TNF-á is a cytokine released from activated macrophages and mast cells. It was identified a little over three decades ago as a protein responsible for lysis of certain types of cells, with specificity for tumor cells. Despite hopes as an anti-tumor agent, significant cytotoxic effects have excluded TNF-á from targeted therapies against multiple diseases such as osteoporosis, atherosclerosis, cancer, allograft rejection, and autoimmune disorders. In order to understand the pleiotropic effects expressed by TNF-á, researchers have attempted to map the functional regions of this gene hoping to discover the amino acid residues related to receptor binding and differentiation, and cytotoxicity. Although many residues critical for biological function have been determined, the exact residues responsible for cytotoxicity and receptor binding affinity have not been located.

Cited by 0

Skin Structure and Function

Lindsey A. Brodell, Kenneth S. Rosenthal · Infectious Diseases in Clinical Practice · 2008

The skin serves as a wall-like barrier to separate and protect the inside of our body from the microbial enemies of the environment and provide a primary defense against infection. The layers of the skin, like the outer wall and secondary inner walls surrounding a medieval city, not only provide protection from external enemies, but also provide niches where normal flora bacteria and fungi can live and conduct business. The structure of the skin and its antimicrobial properties are presented with a discussion of examples of microbes that overcome these protections to cause disease.

Cited by 30

RNA Structure–Function Probing

Douglas T. Gjerde, Lee Hoang, D. Hornby · 2009

This chapter contains sections titled: Definition of the Structure–Function Paradigm Structure Determination of RNA Footprinting, Model Building, and Functional Investigations References

Cited by 0

Antibody Structure and Function

Stephen Searle, Jan T. Pedersen, Andrew Henry et al. · 1995

Abstract The remarkably diverse specificity of antibodies can now be explained both in genetic and structural terms. In the early 1970s Wu and Kabat compared the amino acid sequences of immunoglobulin variable domains and showed that certain segments of sequence were more or less conserved while others exhibited high variability between one sequence and another. They proposed that the highly variable segments, or complementarity determining regions (CDRs), formed a contiguous structural element at one end of the antibody that was responsible for antigen recognition. Ip. 1973, this prediction was confirmed by Poljak and coworkers who reported the first X-ray crystallographic structure of an antibody Fab fragment that contained the antigen binding region.

Cited by 7

Structure, Function and Growth

Lawrence K. Frank · Philosophy of Science · 1935

Today we are in the midst of a far-reaching shift in scientific thought involving the recasting of many of our long-cherished ideas and preconceptions. To some this appears but the orderly evolution of scientific thought, while to others it portends a revolution in both the ideas and the methods of scientific inquiry.

Cited by 13

Molecular Structure and Function

A. Malcolm Campbell, Christopher J. Paradise · 2016

One of the overarching themes in nature is that form meets function, meaning that the shape of an object determines how well the object can perform its function. This book begins with some basics about specificity of shapes and the four increasing levels of protein structure. Most of this book examines how epinephrine (adrenaline) can cause the liver to release glucose when a person experiences a fight or flight response. Whenever someone gets scared, all of their cells are bathed in epinephrine. A subset of those cells will respond directly to this hormone, and the liver cells prepare other cells for the extra energy they might need to survive. This book presents some of the data that revealed how the information of fear is carried inside liver cells. This book will also consider how and why some cell membranes are wavy. In short, this book looks at the structure/ function relationship at the molecular level.

Cited by 0

Transverse Spin Structure Function

H. Bagherpour, M. Saeedhosseini · ISRN High Energy Physics · 2013

The transverse spin-dependent nucleon structure function at large is computed within the Wandzura-Wilczek relation, using NLO fit. Also we investigate the twist-3 contribution of via calculating . It turns out that although the twist-3 part of can be negligible for DIS processes, it has a significant value in resonance region.

Cited by 0Open access